Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

Volker Mall; Florian Heinen; Andrea Siebel; Christoph Bertram; Ulrich Hafkemeyer; Jörg Wissel; Steffen Berweck; Fritz Haverkamp; Günter Nass; Leo Döderlein; Nico Breitbach-Faller; Wilhelm Schulte-Mattler; Rudolf Korinthenberg

doi:10.1017/S0012162206000041

Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

Volker Mall, Florian Heinen, Andrea Siebel, Christoph Bertram, Ulrich Hafkemeyer, Jörg Wissel, Steffen Berweck, Fritz Haverkamp, Günter Nass, Leo Döderlein, Nico Breitbach-Faller, Wilhelm Schulte-Mattler, Rudolf Korinthenberg

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

Original language	English
Pages (from-to)	10-13
Number of pages	4
Journal	Developmental Medicine and Child Neurology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1017/S0012162206000041
State	Published - Jan 2006
Externally published	Yes

Access to Document

10.1017/S0012162206000041

Cite this

Mall, V., Heinen, F., Siebel, A., Bertram, C., Hafkemeyer, U., Wissel, J., Berweck, S., Haverkamp, F., Nass, G., Döderlein, L., Breitbach-Faller, N., Schulte-Mattler, W., & Korinthenberg, R. (2006). Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study. Developmental Medicine and Child Neurology, 48(1), 10-13. https://doi.org/10.1017/S0012162206000041

@article{00f1ba457ebc46b5b831e696ade2c47e,

title = "Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study",

abstract = "Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).",

author = "Volker Mall and Florian Heinen and Andrea Siebel and Christoph Bertram and Ulrich Hafkemeyer and J{\"o}rg Wissel and Steffen Berweck and Fritz Haverkamp and G{\"u}nter Nass and Leo D{\"o}derlein and Nico Breitbach-Faller and Wilhelm Schulte-Mattler and Rudolf Korinthenberg",

year = "2006",

month = jan,

doi = "10.1017/S0012162206000041",

language = "English",

volume = "48",

pages = "10--13",

journal = "Developmental Medicine and Child Neurology",

issn = "0012-1622",

publisher = "Wiley-Blackwell",

number = "1",

}

Mall, V, Heinen, F, Siebel, A, Bertram, C, Hafkemeyer, U, Wissel, J, Berweck, S, Haverkamp, F, Nass, G, Döderlein, L, Breitbach-Faller, N, Schulte-Mattler, W & Korinthenberg, R 2006, 'Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study', Developmental Medicine and Child Neurology, vol. 48, no. 1, pp. 10-13. https://doi.org/10.1017/S0012162206000041

TY - JOUR

T1 - Treatment of adductor spasticity with BTX-A in children with CP

T2 - A randomized, double-blind, placebo-controlled study

AU - Mall, Volker

AU - Heinen, Florian

AU - Siebel, Andrea

AU - Bertram, Christoph

AU - Hafkemeyer, Ulrich

AU - Wissel, Jörg

AU - Berweck, Steffen

AU - Haverkamp, Fritz

AU - Nass, Günter

AU - Döderlein, Leo

AU - Breitbach-Faller, Nico

AU - Schulte-Mattler, Wilhelm

AU - Korinthenberg, Rudolf

PY - 2006/1

Y1 - 2006/1

N2 - Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

AB - Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

UR - http://www.scopus.com/inward/record.url?scp=31144458115&partnerID=8YFLogxK

U2 - 10.1017/S0012162206000041

DO - 10.1017/S0012162206000041

M3 - Article

C2 - 16359588

AN - SCOPUS:31144458115

SN - 0012-1622

VL - 48

SP - 10

EP - 13

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

IS - 1

ER -

Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this