Treatment decision regret in long-term survivors after radical prostatectomy: a longitudinal study

Objectives: To investigate prevalence, course, and predictors of longitudinal decision regret in long-term prostate cancer (PCa) survivors treated by radical prostatectomy (RP). Patients and Methods: A total of 1003 PCa survivors from the multicentre German Familial PCa Database completed questionnaires on average 7 years after RP in 2007 and at follow-up 13 years later in 2020. Patients completed standardised patient-reported outcome measures on decision regret, decision-making, health-related quality of life, and psychosocial factors. Hierarchical multivariable logistic regression was used to assess predictors of longitudinal decision regret. Results: Decision regret increased significantly over time (9.0% after 6.9 years in 2007 and 12% after 19 years in 2020; P = 0.009). Favourable localised PCa (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.05–3.68), decision regret in 2007 (OR 6.38, 95% CI 3.55–11.47), and a higher depression score (OR 1.37, 95% CI 1.03–1.83) were associated with decision regret in 2020. Shared decision-making (OR 0.55, 95% CI 0.33–0.93) was associated with less decision regret. Conclusion: The findings of the present study underline the perseverance of decision regret in long-term PCa survivors and the definitive need for involving patients in the decision-making process to mitigate regret over the long term.