Treat-to-target in atopic dermatitis: An international consensus on a set of core decision points for systemic therapies

Marjolein De Bruin-Weller, Tilo Biedermann, Robert Bissonnette, Mette Deleuran, Peter Foley, Giampiero Girolomoni, Jana Hercogová, Chih Ho Hong, Norito Katoh, Andrew E. Pink, Marie Aleth Richard, Stephen Shumack, Juan F. Silvestre, Stephan Weidinger

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Currently no treat-to-target framework to guide systemic treatment in adults with moderate-to-severe atopic dermatitis exists. We sought to reach international consensus through an eDelphi process on a core set of recommendations for such an approach. Recommendations were developed by an international Steerng Committee, spanning 3 areas (Guiding Principles, Decision Making, and Outcome Thresholds) and 2 specific time-points; an initial acceptable target at 3 months and an optimal target at 6 months, each based on improvements in patient global assessment plus at least one specific outcome domain. These treat-to-targetorientated recommendations were evaluated by an extended international panel of physicians, nurses and patients. Proposed recommendations were rated using a 9-point Likert scale; for each recommendation, consensus agreement was reached if ≥ 75% of all respondents rated agreement as ≥ 7. Consensus on 16 core recommendations was reached over 2 eDelphi rounds. These provide a framework for shared decision-making on systemic treatment continuation, modification, or discontinuation.

Original languageEnglish
Article numberadv00402
JournalActa Dermato-Venereologica
Volume101
Issue number2
DOIs
StatePublished - 2021

Keywords

  • Atopic dermatitis
  • Consensus
  • Edelphi
  • Surveys and questionnaires
  • Systemic treatment
  • Treat-to-target

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