Travelling surface acoustic waves microfluidics

In this paper, we demonstrate the working principle of travelling surface acoustic waves (TSAWs) in a microfluidic system. The TSAWs were incorporated to separate polystyrene (PS) particles of variable diameters and perform controlled mixing of different chemicals for concentration gradient generation, both inside a polydimethylsiloxane (PDMS) microfluidic channel. The TSAWs generated an acoustic streaming flow (ASF) upon coupling with a liquid and exerted an acoustic radiation force (ARF) on the suspended particles. The ARF was theoretically estimated for PS microspheres suspended in water, and conditions for ARF dominance over ASF or vice versa were identified. Recently reported TSAW-based PS particles separation and gradient generation results by our group are summarized here.