Abstract
A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.
Original language | English |
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Pages (from-to) | 14718-14722 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 17 |
Issue number | 52 |
DOIs | |
State | Published - 23 Dec 2011 |
Keywords
- gallium-68
- macrocyclic ligands
- molecular imaging
- positron emission tomography
- radiopharmaceuticals