TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals

Johannes Notni; Jakub Šimeček; Petr Hermann; Hans Jürgen Wester

doi:10.1002/chem.201103503

TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals

Johannes Notni, Jakub Šimeček, Petr Hermann, Hans Jürgen Wester

Default

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga ³⁺ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for ⁶⁸Ga positron emission tomography (PET) imaging agent elaboration.

Original language	English
Pages (from-to)	14718-14722
Number of pages	5
Journal	Chemistry - A European Journal
Volume	17
Issue number	52
DOIs	https://doi.org/10.1002/chem.201103503
State	Published - 23 Dec 2011

Keywords

gallium-68
macrocyclic ligands
molecular imaging
positron emission tomography
radiopharmaceuticals

Access to Document

10.1002/chem.201103503

Cite this

@article{592c7ff7fa774cf8893cdcfc544848c2,

title = "TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals",

abstract = "A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.",

keywords = "gallium-68, macrocyclic ligands, molecular imaging, positron emission tomography, radiopharmaceuticals",

author = "Johannes Notni and Jakub {\v S}ime{\v c}ek and Petr Hermann and Wester, {Hans J{\"u}rgen}",

year = "2011",

month = dec,

day = "23",

doi = "10.1002/chem.201103503",

language = "English",

volume = "17",

pages = "14718--14722",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "52",

}

TY - JOUR

T1 - TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals

AU - Notni, Johannes

AU - Šimeček, Jakub

AU - Hermann, Petr

AU - Wester, Hans Jürgen

PY - 2011/12/23

Y1 - 2011/12/23

N2 - A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.

AB - A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.

KW - gallium-68

KW - macrocyclic ligands

KW - molecular imaging

KW - positron emission tomography

KW - radiopharmaceuticals

UR - http://www.scopus.com/inward/record.url?scp=83755163221&partnerID=8YFLogxK

U2 - 10.1002/chem.201103503

DO - 10.1002/chem.201103503

M3 - Article

C2 - 22147338

AN - SCOPUS:83755163221

SN - 0947-6539

VL - 17

SP - 14718

EP - 14722

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 52

ER -

TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this