TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals

Johannes Notni, Jakub Šimeček, Petr Hermann, Hans Jürgen Wester

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


A veritable gallium TRAP: Triazacyclononane-phosphinic acid chelators (TRAP) form highly stable complexes with Ga 3+ (see figure) extremely efficiently over a wide pH range. Homo- and heteromultimeric bioconjugates can be synthesized in a straightforward manner, all of which renders TRAP a chelator with ideal properties for 68Ga positron emission tomography (PET) imaging agent elaboration.

Original languageEnglish
Pages (from-to)14718-14722
Number of pages5
JournalChemistry - A European Journal
Issue number52
StatePublished - 23 Dec 2011


  • gallium-68
  • macrocyclic ligands
  • molecular imaging
  • positron emission tomography
  • radiopharmaceuticals


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