Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors

Berkan Lafci; Elena Merčep; Joaquin L. Herraiz; Xosé Luís Deán-Ben; Daniel Razansky

doi:10.1117/12.2577907

Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors

Berkan Lafci
, Elena Merčep
, Joaquin L. Herraiz
, Xosé Luís Deán-Ben
, Daniel Razansky

University of Zurich
Technical University of Munich
iThera Medical GmbH
Universidad Complutense de Madrid
Hospital Clínico San Carlos

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Ultrasound (US) and optoacoustic (OA) imaging provide complementary information for quantitative analysis of the tumor microenvironment. Herein, we demonstrate the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS) for characterizing breast cancer in tumor-bearing mice. For this, 4 different mice featuring orthotopic tumor of different sizes were scanned with a full-ring ultrasound transducer array to simultaneously render pulse-echo US images, speed of sound (SoS) maps and OA images. The tumor size, vascular density and its elastic parameters were further quantified in the images. Our results pave the way toward clinical translation of the hybrid TROPUS imaging for tumor detection and characterization.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2021
Editors	Alexander A. Oraevsky, Lihong V. Wang
Publisher	SPIE
ISBN (Electronic)	9781510641198
DOIs	https://doi.org/10.1117/12.2577907
State	Published - 2021
Externally published	Yes
Event	Photons Plus Ultrasound: Imaging and Sensing 2021 - Virtual, Online, United States Duration: 6 Mar 2021 → 11 Mar 2021

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11642
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2021
Country/Territory	United States
City	Virtual, Online
Period	6/03/21 → 11/03/21

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer research
Optoacoustic imaging
Photoacoustics
Preclinical imaging of tumors
Speed of sound imaging
Ultrasound computed tomography

Access to Document

10.1117/12.2577907

Cite this

Lafci, B., Merčep, E., Herraiz, J. L., Deán-Ben, X. L., & Razansky, D. (2021). Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2021 Article 116422L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11642). SPIE. https://doi.org/10.1117/12.2577907

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title = "Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors",

abstract = "Ultrasound (US) and optoacoustic (OA) imaging provide complementary information for quantitative analysis of the tumor microenvironment. Herein, we demonstrate the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS) for characterizing breast cancer in tumor-bearing mice. For this, 4 different mice featuring orthotopic tumor of different sizes were scanned with a full-ring ultrasound transducer array to simultaneously render pulse-echo US images, speed of sound (SoS) maps and OA images. The tumor size, vascular density and its elastic parameters were further quantified in the images. Our results pave the way toward clinical translation of the hybrid TROPUS imaging for tumor detection and characterization.",

keywords = "Cancer research, Optoacoustic imaging, Photoacoustics, Preclinical imaging of tumors, Speed of sound imaging, Ultrasound computed tomography",

author = "Berkan Lafci and Elena Mer{\v c}ep and Herraiz, \{Joaquin L.\} and De{\'a}n-Ben, \{Xos{\'e} Lu{\'i}s\} and Daniel Razansky",

note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Photons Plus Ultrasound: Imaging and Sensing 2021 ; Conference date: 06-03-2021 Through 11-03-2021",

year = "2021",

doi = "10.1117/12.2577907",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Oraevsky, \{Alexander A.\} and Wang, \{Lihong V.\}",

booktitle = "Photons Plus Ultrasound",

}

Lafci, B, Merčep, E, Herraiz, JL, Deán-Ben, XL & Razansky, D 2021, Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors. in AA Oraevsky & LV Wang (eds), Photons Plus Ultrasound: Imaging and Sensing 2021., 116422L, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11642, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2021, Virtual, Online, United States, 6/03/21. https://doi.org/10.1117/12.2577907

Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors. / Lafci, Berkan; Merčep, Elena; Herraiz, Joaquin L. et al.
Photons Plus Ultrasound: Imaging and Sensing 2021. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2021. 116422L (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11642).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors

AU - Lafci, Berkan

AU - Merčep, Elena

AU - Herraiz, Joaquin L.

AU - Deán-Ben, Xosé Luís

AU - Razansky, Daniel

N1 - Publisher Copyright: © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

PY - 2021

Y1 - 2021

N2 - Ultrasound (US) and optoacoustic (OA) imaging provide complementary information for quantitative analysis of the tumor microenvironment. Herein, we demonstrate the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS) for characterizing breast cancer in tumor-bearing mice. For this, 4 different mice featuring orthotopic tumor of different sizes were scanned with a full-ring ultrasound transducer array to simultaneously render pulse-echo US images, speed of sound (SoS) maps and OA images. The tumor size, vascular density and its elastic parameters were further quantified in the images. Our results pave the way toward clinical translation of the hybrid TROPUS imaging for tumor detection and characterization.

AB - Ultrasound (US) and optoacoustic (OA) imaging provide complementary information for quantitative analysis of the tumor microenvironment. Herein, we demonstrate the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS) for characterizing breast cancer in tumor-bearing mice. For this, 4 different mice featuring orthotopic tumor of different sizes were scanned with a full-ring ultrasound transducer array to simultaneously render pulse-echo US images, speed of sound (SoS) maps and OA images. The tumor size, vascular density and its elastic parameters were further quantified in the images. Our results pave the way toward clinical translation of the hybrid TROPUS imaging for tumor detection and characterization.

KW - Cancer research

KW - Optoacoustic imaging

KW - Photoacoustics

KW - Preclinical imaging of tumors

KW - Speed of sound imaging

KW - Ultrasound computed tomography

UR - https://www.scopus.com/pages/publications/85109103588

U2 - 10.1117/12.2577907

DO - 10.1117/12.2577907

M3 - Conference contribution

AN - SCOPUS:85109103588

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

A2 - Oraevsky, Alexander A.

A2 - Wang, Lihong V.

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2021

Y2 - 6 March 2021 through 11 March 2021

ER -

Transmission-reflection optoacoustic ultrasound (TROPUS) imaging of mammary tumors

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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