Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

H. Meisel; A. Reip; B. Faltus; D. H. Krüger; H. Porst; M. Wiese; M. Lu; M. Roggendorf

doi:10.1016/S0140-6736(95)91992-9

Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

H. Meisel, A. Reip, B. Faltus, D. H. Krüger, H. Porst, M. Wiese, M. Lu, M. Roggendorf

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

Original language	English
Pages (from-to)	1209-1211
Number of pages	3
Journal	The Lancet
Volume	345
Issue number	8959
DOIs	https://doi.org/10.1016/S0140-6736(95)91992-9
State	Published - 13 May 1995
Externally published	Yes

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10.1016/S0140-6736(95)91992-9

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title = "Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin",

abstract = "In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.",

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T1 - Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

AU - Meisel, H.

AU - Reip, A.

AU - Faltus, B.

AU - Krüger, D. H.

AU - Porst, H.

AU - Wiese, M.

AU - Lu, M.

AU - Roggendorf, M.

PY - 1995/5/13

Y1 - 1995/5/13

N2 - In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

AB - In 1978-79 a single-source outbreak of hepatitis C occurred in 2533 women who had received virus- contaminated anti-D immunoglobulin. Children and husbands of 74 women with self-limited, and of 86 women with chronic, hepatitis C were followed up for over 10-15 years. In 3 of 231 investigated children (1·3%) serological evidence for HCV infection was found. However, none of the children developed an apparent or chronic hepatitis. Serum samples of the 94 husbands investigated showed no HCV antibodies or HCV RNA. We consider the risk of intrauterine or perinatal transmission of HCV, as well as that of transmission through close family contacts, to be low. No evidence was found for sexual transmission from women to men.

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Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin

Abstract

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