@article{2dc258f70b884322b39d6baba38cb0ea,
title = "Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders",
abstract = "The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system. One of its main functions is the transport of the substrate cholesterol into mitochondria, a prerequisite for steroid synthesis. TSPO expression may constitute a biomarker of brain inflammation and reactive gliosis that could be monitored by using TSPO ligands as neuroimaging agents. Moreover, initial clinical trials have indicated that TSPO ligands might be valuable in the treatment of neurological and psychiatric disorders. This Review focuses on the biology and pathophysiology of TSPO and the potential of currently available TSPO ligands for the diagnosis and treatment of neurological and psychiatric disorders.",
author = "Rainer Rupprecht and Vassilios Papadopoulos and Gerhard Rammes and Baghai, {Thomas C.} and Jinjiang Fan and Nagaraju Akula and Ghislaine Groyer and David Adams and Michael Schumacher",
note = "Funding Information: We thank H. Mohler and F. Holsboer for their insightful comments on the work. We acknowledge funding support from a Max Planck Fellow grant to R.R. V.P. was supported by grants from the US National Institutes of Health (ES07747), the Canadian Institutes of Health Research (211,033), and a Canada Research Chair. G.G. was supported by a grant from the Association Fran{\c c}aise contre les Myopathies (AFM) and by Biocodex, France. D.A. was supported by a Plan Pluriformation (“Peripheral and spinal axonal regeneration”) from the University Paris-Sud 11, France. M.S. is the beneficiary of an Interface Program of the Institut National de la Sant{\'e} et de la Recherche M{\'e}dicale and the Assistance Publique-H{\^o}pitaux de Paris, France.",
year = "2010",
month = dec,
doi = "10.1038/nrd3295",
language = "English",
volume = "9",
pages = "971--988",
journal = "Nature Reviews Drug Discovery",
issn = "1474-1776",
publisher = "Nature Research",
number = "12",
}