Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

Christian Appenzeller-Herzog; Gabor Bánhegyi; Ivan Bogeski; Kelvin J.A. Davies; Agnès Delaunay-Moisan; Henry Jay Forman; Agnes Görlach; Thomas Kietzmann; Francisco Laurindo; Eva Margittai; Andreas J. Meyer; Jan Riemer; Michael Rützler; Thomas Simmen; Roberto Sitia; Michel B. Toledano; Ivo P. Touw

doi:10.1016/j.freeradbiomed.2016.02.030

Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish

Christian Appenzeller-Herzog, Gabor Bánhegyi, Ivan Bogeski, Kelvin J.A. Davies, Agnès Delaunay-Moisan, Henry Jay Forman, Agnes Görlach, Thomas Kietzmann, Francisco Laurindo, Eva Margittai, Andreas J. Meyer, Jan Riemer, Michael Rützler, Thomas Simmen, Roberto Sitia, Michel B. Toledano, Ivo P. Touw

Associate Professorship of Cardiovascular Biology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Cellular metabolism provides various sources of hydrogen peroxide (H₂O₂) in different organelles and compartments. The suitability of H₂O₂ as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H₂O₂ has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H₂O₂ diffusion and support earlier data showing that (i) ample H₂O₂ permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H₂O₂ permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H₂O₂ permeation in signal transduction and organelle biology.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Free Radical Biology and Medicine
Volume	94
DOIs	https://doi.org/10.1016/j.freeradbiomed.2016.02.030
State	Published - 1 May 2016

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Appenzeller-Herzog, C., Bánhegyi, G., Bogeski, I., Davies, K. J. A., Delaunay-Moisan, A., Forman, H. J., Görlach, A., Kietzmann, T., Laurindo, F., Margittai, E., Meyer, A. J., Riemer, J., Rützler, M., Simmen, T., Sitia, R., Toledano, M. B., & Touw, I. P. (2016). Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish. Free Radical Biology and Medicine, 94, 157-160. https://doi.org/10.1016/j.freeradbiomed.2016.02.030

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title = "Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish",

abstract = "Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.",

author = "Christian Appenzeller-Herzog and Gabor B{\'a}nhegyi and Ivan Bogeski and Davies, {Kelvin J.A.} and Agn{\`e}s Delaunay-Moisan and Forman, {Henry Jay} and Agnes G{\"o}rlach and Thomas Kietzmann and Francisco Laurindo and Eva Margittai and Meyer, {Andreas J.} and Jan Riemer and Michael R{\"u}tzler and Thomas Simmen and Roberto Sitia and Toledano, {Michel B.} and Touw, {Ivo P.}",

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Appenzeller-Herzog, C, Bánhegyi, G, Bogeski, I, Davies, KJA, Delaunay-Moisan, A, Forman, HJ, Görlach, A, Kietzmann, T, Laurindo, F, Margittai, E, Meyer, AJ, Riemer, J, Rützler, M, Simmen, T, Sitia, R, Toledano, MB & Touw, IP 2016, 'Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish', Free Radical Biology and Medicine, vol. 94, pp. 157-160. https://doi.org/10.1016/j.freeradbiomed.2016.02.030

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T1 - Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish

AU - Appenzeller-Herzog, Christian

AU - Bánhegyi, Gabor

AU - Bogeski, Ivan

AU - Davies, Kelvin J.A.

AU - Delaunay-Moisan, Agnès

AU - Forman, Henry Jay

AU - Görlach, Agnes

AU - Kietzmann, Thomas

AU - Laurindo, Francisco

AU - Margittai, Eva

AU - Meyer, Andreas J.

AU - Riemer, Jan

AU - Rützler, Michael

AU - Simmen, Thomas

AU - Sitia, Roberto

AU - Toledano, Michel B.

AU - Touw, Ivo P.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.

AB - Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challenge the recent proposal that the ER membrane constitutes a simple barrier for H2O2 diffusion and support earlier data showing that (i) ample H2O2 permeability of the ER membrane is a prerequisite for signal transduction, (ii) aquaporin channels are crucially involved in the facilitation of H2O2 permeation, and (iii) a proper experimental framework not prone to artifacts is necessary to further unravel the role of H2O2 permeation in signal transduction and organelle biology.

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ER -

Transit of H₂O₂ across the endoplasmic reticulum membrane is not sluggish

Abstract

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