TY - JOUR
T1 - Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
AU - Vinegoni, Claudio
AU - Razansky, Daniel
AU - Hilderbrand, Scott A.
AU - Shao, Fangwei
AU - Ntziachristos, Vasilis
AU - Weissleder, Ralph
PY - 2009/9/1
Y1 - 2009/9/1
N2 - We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received biocompatible upconverting nanoparticles. The method holds great promise for artifact-free whole-body visualization of optical molecular probes.
AB - We report on a systematic study of upconverting fluorescence signal generation within turbid phantoms and real tissues. An accurate three-point Green's function, describing the forward model of photon propagation, is established and experimentally validated. We further demonstrate, for the first time to our knowledge, autofluorescence-free transillumination imaging of mice that have received biocompatible upconverting nanoparticles. The method holds great promise for artifact-free whole-body visualization of optical molecular probes.
UR - http://www.scopus.com/inward/record.url?scp=69549133485&partnerID=8YFLogxK
U2 - 10.1364/OL.34.002566
DO - 10.1364/OL.34.002566
M3 - Article
C2 - 19724491
AN - SCOPUS:69549133485
SN - 0146-9592
VL - 34
SP - 2566
EP - 2568
JO - Optics Letters
JF - Optics Letters
IS - 17
ER -