TY - JOUR
T1 - Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients
AU - Binder, Andreas
AU - May, Denisa
AU - Baron, Ralf
AU - Maier, Christoph
AU - Tölle, Thomas R.
AU - Treede, Rolf Detlef
AU - Berthele, Achim
AU - Faltraco, Frank
AU - Flor, Herta
AU - Gierthmühlen, Janne
AU - Haenisch, Sierk
AU - Huge, Volker
AU - Magerl, Walter
AU - Maihöfner, Christian
AU - Richter, Helmut
AU - Rolke, Roman
AU - Scherens, Andrea
AU - Üçeyler, Nurcan
AU - Ufer, Mike
AU - Wasner, Gunnar
AU - Zhu, Jihong
AU - Cascorbi, Ingolf
N1 - Funding Information:
A. Binder received support for travel from the BMBF, honoraria for lectures from Grünenthal, Allergan and Pfizer, payment for development of educational presentations from Pfizer and travel/accommodation expenses from Pfizer, Allergan and Grünenthal and his institution received financial support from the BMBF. RB received support for travel from the BMBF, has consultancies with and received honoraria and travel/accommodation expenses from Pfizer, Genzyme, Grünenthal, Mundipharma, Allergan, Sanofi Pasteur, Medtronic, Eisai, UCB, Lilly, Astellas, received grants from Pfizer, Grünenthal, Genzyme, received payment for development of educational presentations from Pfizer, Medtronic and his institution received financial support from the BMBF. TT is board member at Pfizer, Lilly, Boehringer Grünenthal, and has consultancies with and received travel /accommodation expenses from Pfizer, Lilly, Boehringer, Grünenthal, Mundipharma, UCB/Schwarz. A. Berthele received honoraria and travel/accommodations expenses from Pfizer and his institution a grant from the BMBF. JG received support for travel from the BMBF and her institution received financial support from the BMBF. VH's institution received financial support from the BMBF. CMh received honoraria from Pfizer and travel/accommodation expenses from Allergan. RR is a board member at Astellas Pharma and received honoraria for lectures from Lilly and Pfizer. GW received honoraria and travel/accommodation expenses from Grünenthal, Medtronic, Pfizer, Mundipharma, his institution received financial support from the BMBF and Pfizer Pharma, and he received financial support for research from the National Health and Medical Research Council of Australia (NHMRC), the EFIC-Grünenthal-Grant (EGG), the Ministry of Science, Commerce and Transportation of Schleswig-Holstein, Germany and the Alexander von Humboldt-Stiftung. IC received honoraria and travel/accommodation expenses from MSD, Bayer-Schering and Sanofi Aventis for lectures. DM, RDT, FF, HF, SH, CM, AS, MU, NÜ, JZ, WM, HR have disclosed no competing interests. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
PY - 2011
Y1 - 2011
N2 - Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p=0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p=0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p=0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.
AB - Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p=0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p=0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p=0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.
UR - http://www.scopus.com/inward/record.url?scp=79953193743&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0017387
DO - 10.1371/journal.pone.0017387
M3 - Article
C2 - 21468319
AN - SCOPUS:79953193743
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 3
M1 - e17387
ER -