Transcriptome and Metabolome Data Integration-Technical Perquisites for Successful Data Fusion and Visualization

Michael Witting, Philippe Schmitt-Kopplin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

Different types of "Omics" technologies can be combined for a systems biology insight into biological samples. Metabolomics, measurement of the metabolite content of such a system, and transcriptomics, measurement of gene expression, are a preferred combination because of several advantages. Both technologies, especially microarray-based transcriptomics, can be used in routine analysis and are capable of high throughput. In this chapter, we briefly review the process of how metabolomics and transcriptomic data are generated, how they can be combined, and which tools exist for combined analysis. Furthermore, tools for visualization are presented and MassTRIX, a metabolite annotation Web server, also capable of transcriptome data analysis from Affymetrix gene chips, is presented.

Original languageEnglish
Title of host publicationComprehensive Analytical Chemistry
PublisherElsevier B.V.
Pages421-442
Number of pages22
DOIs
StatePublished - 2014

Publication series

NameComprehensive Analytical Chemistry
Volume63
ISSN (Print)0166-526X

Keywords

  • Data fusion
  • MassTRIX
  • Metabolomics
  • Transcriptomics
  • Visualization

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