Transcriptional control of DNA-based nanomachines

Wendy U. Dittmer; Friedrich C. Simmel

doi:10.1021/nl049784v

Transcriptional control of DNA-based nanomachines

Wendy U. Dittmer, Friedrich C. Simmel

University of Munich

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

The construction of autonomous DNA-based nanomachines is an important challenge. To this end we have combined DNA tweezers with the transcription machinery of prokaryotic organisms and created a gene that codes for the production of an mRNA strand to bring about a conformational change in the tweezers. Gel electrophoresis and FRET experiments demonstrate that the transcription process successfully reads out the gene and automatically brings the machine to the desired state.

Original language	English
Pages (from-to)	689-691
Number of pages	3
Journal	Nano Letters
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/nl049784v
State	Published - Apr 2004
Externally published	Yes

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title = "Transcriptional control of DNA-based nanomachines",

abstract = "The construction of autonomous DNA-based nanomachines is an important challenge. To this end we have combined DNA tweezers with the transcription machinery of prokaryotic organisms and created a gene that codes for the production of an mRNA strand to bring about a conformational change in the tweezers. Gel electrophoresis and FRET experiments demonstrate that the transcription process successfully reads out the gene and automatically brings the machine to the desired state.",

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AB - The construction of autonomous DNA-based nanomachines is an important challenge. To this end we have combined DNA tweezers with the transcription machinery of prokaryotic organisms and created a gene that codes for the production of an mRNA strand to bring about a conformational change in the tweezers. Gel electrophoresis and FRET experiments demonstrate that the transcription process successfully reads out the gene and automatically brings the machine to the desired state.

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Transcriptional control of DNA-based nanomachines

Abstract

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