TY - JOUR
T1 - Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk
T2 - A case-control study
AU - Burwinkel, Barbara
AU - Shanmugam, Kalai S.
AU - Hemminki, Kari
AU - Meindl, Alfons
AU - Schmutzler, Rita K.
AU - Sutter, Christian
AU - Wappenschmidt, Barbara
AU - Kiechle, Marion
AU - Bartram, Claus R.
AU - Frank, Bernd
PY - 2006/11/17
Y1 - 2006/11/17
N2 - Background: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs 12233372, were identified to associate with type 2 diabetes. Methods: We investigated the effect of the TCF7L2 rs 12255372 variant on familial breast cancer (BC) risk by means of TaqMan allelic discrimination, analyzing BRCA1/2 mutation-negative index patients of 592 German BC families and 735 control individuals. Results: The T allele of rs12255372 showed an association with borderline significance (OR = 1.19, 95% C.I. = 1.01-1.42, P = 0.04), and the Cochran-Armitage test for trend revealed an allele dose-dependent association of rs12255372 with BC risk (Ptrend = 0.04). Conclusion: Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC.
AB - Background: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs 12233372, were identified to associate with type 2 diabetes. Methods: We investigated the effect of the TCF7L2 rs 12255372 variant on familial breast cancer (BC) risk by means of TaqMan allelic discrimination, analyzing BRCA1/2 mutation-negative index patients of 592 German BC families and 735 control individuals. Results: The T allele of rs12255372 showed an association with borderline significance (OR = 1.19, 95% C.I. = 1.01-1.42, P = 0.04), and the Cochran-Armitage test for trend revealed an allele dose-dependent association of rs12255372 with BC risk (Ptrend = 0.04). Conclusion: Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC.
UR - http://www.scopus.com/inward/record.url?scp=33845228965&partnerID=8YFLogxK
U2 - 10.1186/1471-2407-6-268
DO - 10.1186/1471-2407-6-268
M3 - Article
C2 - 17109766
AN - SCOPUS:33845228965
SN - 1471-2407
VL - 6
JO - BMC Cancer
JF - BMC Cancer
M1 - 268
ER -
