Trace determination of pharmaceuticals and other wastewater-derived micropollutants by solid phase extraction and gas chromatography/mass spectrometry

Kevin J. Bisceglia, Jim T. Yu, Mehmet Coelhan, Edward J. Bouwer, A. Lynn Roberts

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

The presence of pharmaceuticals and other wastewater-derived micropollutants in surface and groundwaters is receiving intense public and scientific attention. Yet simple GC/MS methods that would enable measurement of a wide range of such compounds are scarce. This paper describes a GC/MS method for the simultaneous determination of 13 pharmaceuticals (acetaminophen, albuterol, allopurinol, amitriptyline, brompheniramine, carbamazepine, carisoprodol, ciclopirox, diazepam, fenofibrate, metoprolol, primidone, and terbinafine) and 5 wastewater-derived contaminants (caffeine, diethyltoluamide, n-butylbenzene sulfonamide, n-nonylphenol, and n-octylphenol) by solid phase extraction (SPE) and derivatization with BSTFA. The method was applied to the analysis of raw and treated sewage samples obtained from a wastewater treatment plant located in the mid-Atlantic United States. All analytes were detected in untreated sewage, and 14 of the 18 analytes were detected in treated sewage.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalJournal of Chromatography A
Volume1217
Issue number4
DOIs
StatePublished - 22 Jan 2010

Keywords

  • Environmental occurrence
  • Gas chromatography/mass spectrometry
  • PPCPs
  • Pharmaceuticals
  • Sewage
  • Wastewater

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