Toxicokinetic Models

Johannes Georg Filser

doi:10.1007/978-3-030-57499-4_49

Toxicokinetic Models

Johannes Georg Filser

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Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Toxicokinetics describes by means of mathematical functions the time-and dose-dependent processes of absorption, distribution, and elimination of a chemical substance and metabolites thereof in animals and humans. For this purpose, classical compartment open models and physiologically based toxicokinetic models are used. Both are applied to fit concentration-time data and to predict concentration-time courses of a parent chemical and metabolites usually in blood or plasma for repeated or continuous exposures; the latter models enable additionally to predict such time courses in various tissues and organs. An introduction is given into toxicokinetic modeling exemplified by two classical compartment open models and a physiologically based toxicokinetic model.

Original language	English
Title of host publication	Regulatory Toxicology
Subtitle of host publication	Volumes 1-2, Second Edition
Publisher	Springer International Publishing
Pages	407-418
Number of pages	12
Volume	1
ISBN (Electronic)	9783030574994
ISBN (Print)	9783030574987
DOIs	https://doi.org/10.1007/978-3-030-57499-4_49
State	Published - 1 Jan 2021

Keywords

Inhalation toxicology
Interspecies scaling
One-compartment open model
PBTK model
Physiologically based toxicokinetic model
Saturation kinetics
Toxicokinetics
Two-compartment open model

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10.1007/978-3-030-57499-4_49

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title = "Toxicokinetic Models",

abstract = "Toxicokinetics describes by means of mathematical functions the time-and dose-dependent processes of absorption, distribution, and elimination of a chemical substance and metabolites thereof in animals and humans. For this purpose, classical compartment open models and physiologically based toxicokinetic models are used. Both are applied to fit concentration-time data and to predict concentration-time courses of a parent chemical and metabolites usually in blood or plasma for repeated or continuous exposures; the latter models enable additionally to predict such time courses in various tissues and organs. An introduction is given into toxicokinetic modeling exemplified by two classical compartment open models and a physiologically based toxicokinetic model.",

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author = "Filser, {Johannes Georg}",

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doi = "10.1007/978-3-030-57499-4_49",

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AU - Filser, Johannes Georg

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021.

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N2 - Toxicokinetics describes by means of mathematical functions the time-and dose-dependent processes of absorption, distribution, and elimination of a chemical substance and metabolites thereof in animals and humans. For this purpose, classical compartment open models and physiologically based toxicokinetic models are used. Both are applied to fit concentration-time data and to predict concentration-time courses of a parent chemical and metabolites usually in blood or plasma for repeated or continuous exposures; the latter models enable additionally to predict such time courses in various tissues and organs. An introduction is given into toxicokinetic modeling exemplified by two classical compartment open models and a physiologically based toxicokinetic model.

AB - Toxicokinetics describes by means of mathematical functions the time-and dose-dependent processes of absorption, distribution, and elimination of a chemical substance and metabolites thereof in animals and humans. For this purpose, classical compartment open models and physiologically based toxicokinetic models are used. Both are applied to fit concentration-time data and to predict concentration-time courses of a parent chemical and metabolites usually in blood or plasma for repeated or continuous exposures; the latter models enable additionally to predict such time courses in various tissues and organs. An introduction is given into toxicokinetic modeling exemplified by two classical compartment open models and a physiologically based toxicokinetic model.

KW - Inhalation toxicology

KW - Interspecies scaling

KW - One-compartment open model

KW - PBTK model

KW - Physiologically based toxicokinetic model

KW - Saturation kinetics

KW - Toxicokinetics

KW - Two-compartment open model

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DO - 10.1007/978-3-030-57499-4_49

M3 - Chapter

AN - SCOPUS:85160749865

SN - 9783030574987

VL - 1

SP - 407

EP - 418

BT - Regulatory Toxicology

PB - Springer International Publishing

ER -

Toxicokinetic Models

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Keywords

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