Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes

Dzhoshkun I. Shakir; Aslı Okur; Alexander Hartl; Philipp Matthies; Sibylle I. Ziegler; Markus Essler; Tobias Lasser; Nassir Navab

doi:10.1007/978-3-642-33415-3_53

Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes

Dzhoshkun I. Shakir, Aslı Okur, Alexander Hartl, Philipp Matthies, Sibylle I. Ziegler, Markus Essler, Tobias Lasser, Nassir Navab

Informatics 16 - Chair of Computer Aided Medical Procedures

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

6 Scopus citations

Abstract

We present a novel approach for intra-operative localization of lymph nodes and metastases in the head and neck region using the radio-tracer [¹⁸F]FDG. By combining an optical tracking system with a high-energy gamma probe to detect 511keV annihilation gammas, we enable intra-operative PET to visualize activity distributions. Detection of these gammas is modeled ad-hoc analytically, taking into account several factors affecting the detection process. This allows us to iteratively reconstruct the radio-tracer distribution within a localized volume of interest. As a feasibility study we analyze clinical data of 7 patients with tumors in the head and neck region, and derive a realistic neck phantom configuration with [¹⁸F]FDG-filled lesions mimicking tumors and lymph nodes. We demonstrate the capabilities and limitations of our approach using that neck phantom. We also outline possible improvements to make our method clinically viable towards less invasive surgeries.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings
Editors	Nicholas Ayache, Herve Delingette, Polina Golland, Kensaku Mori
Publisher	Springer Verlag
Pages	430-437
Number of pages	8
ISBN (Print)	9783642334146
DOIs	https://doi.org/10.1007/978-3-642-33415-3_53
State	Published - 2012
Event	15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012 - Nice, France Duration: 1 Oct 2012 → 5 Oct 2012

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	7510 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012
Country/Territory	France
City	Nice
Period	1/10/12 → 5/10/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-642-33415-3_53

Cite this

Shakir, D. I., Okur, A., Hartl, A., Matthies, P., Ziegler, S. I., Essler, M., Lasser, T., & Navab, N. (2012). Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes. In N. Ayache, H. Delingette, P. Golland, & K. Mori (Eds.), Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings (pp. 430-437). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7510 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-642-33415-3_53

Shakir, Dzhoshkun I. ; Okur, Aslı ; Hartl, Alexander et al. / Towards intra-operative PET for head and neck cancer : Lymph node localization using high-energy probes. Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings. editor / Nicholas Ayache ; Herve Delingette ; Polina Golland ; Kensaku Mori. Springer Verlag, 2012. pp. 430-437 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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title = "Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes",

abstract = "We present a novel approach for intra-operative localization of lymph nodes and metastases in the head and neck region using the radio-tracer [18F]FDG. By combining an optical tracking system with a high-energy gamma probe to detect 511keV annihilation gammas, we enable intra-operative PET to visualize activity distributions. Detection of these gammas is modeled ad-hoc analytically, taking into account several factors affecting the detection process. This allows us to iteratively reconstruct the radio-tracer distribution within a localized volume of interest. As a feasibility study we analyze clinical data of 7 patients with tumors in the head and neck region, and derive a realistic neck phantom configuration with [18F]FDG-filled lesions mimicking tumors and lymph nodes. We demonstrate the capabilities and limitations of our approach using that neck phantom. We also outline possible improvements to make our method clinically viable towards less invasive surgeries.",

author = "Shakir, {Dzhoshkun I.} and Aslı Okur and Alexander Hartl and Philipp Matthies and Ziegler, {Sibylle I.} and Markus Essler and Tobias Lasser and Nassir Navab",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag Berlin Heidelberg 2012.; 15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012 ; Conference date: 01-10-2012 Through 05-10-2012",

year = "2012",

doi = "10.1007/978-3-642-33415-3_53",

language = "English",

isbn = "9783642334146",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "430--437",

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}

Shakir, DI, Okur, A, Hartl, A, Matthies, P, Ziegler, SI, Essler, M, Lasser, T & Navab, N 2012, Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes. in N Ayache, H Delingette, P Golland & K Mori (eds), Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 7510 LNCS, Springer Verlag, pp. 430-437, 15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012, Nice, France, 1/10/12. https://doi.org/10.1007/978-3-642-33415-3_53

Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes. / Shakir, Dzhoshkun I.; Okur, Aslı; Hartl, Alexander et al.
Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings. ed. / Nicholas Ayache; Herve Delingette; Polina Golland; Kensaku Mori. Springer Verlag, 2012. p. 430-437 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7510 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Towards intra-operative PET for head and neck cancer

T2 - 15th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2012

AU - Shakir, Dzhoshkun I.

AU - Okur, Aslı

AU - Hartl, Alexander

AU - Matthies, Philipp

AU - Ziegler, Sibylle I.

AU - Essler, Markus

AU - Lasser, Tobias

AU - Navab, Nassir

PY - 2012

Y1 - 2012

N2 - We present a novel approach for intra-operative localization of lymph nodes and metastases in the head and neck region using the radio-tracer [18F]FDG. By combining an optical tracking system with a high-energy gamma probe to detect 511keV annihilation gammas, we enable intra-operative PET to visualize activity distributions. Detection of these gammas is modeled ad-hoc analytically, taking into account several factors affecting the detection process. This allows us to iteratively reconstruct the radio-tracer distribution within a localized volume of interest. As a feasibility study we analyze clinical data of 7 patients with tumors in the head and neck region, and derive a realistic neck phantom configuration with [18F]FDG-filled lesions mimicking tumors and lymph nodes. We demonstrate the capabilities and limitations of our approach using that neck phantom. We also outline possible improvements to make our method clinically viable towards less invasive surgeries.

AB - We present a novel approach for intra-operative localization of lymph nodes and metastases in the head and neck region using the radio-tracer [18F]FDG. By combining an optical tracking system with a high-energy gamma probe to detect 511keV annihilation gammas, we enable intra-operative PET to visualize activity distributions. Detection of these gammas is modeled ad-hoc analytically, taking into account several factors affecting the detection process. This allows us to iteratively reconstruct the radio-tracer distribution within a localized volume of interest. As a feasibility study we analyze clinical data of 7 patients with tumors in the head and neck region, and derive a realistic neck phantom configuration with [18F]FDG-filled lesions mimicking tumors and lymph nodes. We demonstrate the capabilities and limitations of our approach using that neck phantom. We also outline possible improvements to make our method clinically viable towards less invasive surgeries.

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DO - 10.1007/978-3-642-33415-3_53

M3 - Conference contribution

C2 - 23285580

AN - SCOPUS:84872557848

SN - 9783642334146

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 430

EP - 437

BT - Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings

A2 - Ayache, Nicholas

A2 - Delingette, Herve

A2 - Golland, Polina

A2 - Mori, Kensaku

PB - Springer Verlag

Y2 - 1 October 2012 through 5 October 2012

ER -

Shakir DI, Okur A, Hartl A, Matthies P, Ziegler SI, Essler M et al. Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes. In Ayache N, Delingette H, Golland P, Mori K, editors, Medical Image Computing and Computer-Assisted Intervention, MICCAI2012 - 15th International Conference, Proceedings. Springer Verlag. 2012. p. 430-437. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-642-33415-3_53

Towards intra-operative PET for head and neck cancer: Lymph node localization using high-energy probes

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