TY - GEN
T1 - Towards in vivo nanomachines
AU - Friedrichs, Eike
AU - Jungmann, Ralf
AU - Tsokou, Angeliki
AU - Renner, Stephan
AU - Simmel, Friedrich C.
PY - 2008
Y1 - 2008
N2 - DNA has been recently used to construct a variety of nanoscale machines and switches, among them devices which can translocate, compute, or bind and release molecules. For future applications it is interesting to investigate whether these "artificial" functions can also be implemented in vivo. As one step towards in vivo applications, we currently utilize RNA molecules for construction or control of molecular devices. RNA molecules can be transcribed from "artificial genes" and either fold into functional nanoassemblies themselves or drive other nucleic acid-based devices as a "fuel". Furthermore, coupling of nanomachines to RNA transcription enables control of their behavior using gene regulatory motifs.
AB - DNA has been recently used to construct a variety of nanoscale machines and switches, among them devices which can translocate, compute, or bind and release molecules. For future applications it is interesting to investigate whether these "artificial" functions can also be implemented in vivo. As one step towards in vivo applications, we currently utilize RNA molecules for construction or control of molecular devices. RNA molecules can be transcribed from "artificial genes" and either fold into functional nanoassemblies themselves or drive other nucleic acid-based devices as a "fuel". Furthermore, coupling of nanomachines to RNA transcription enables control of their behavior using gene regulatory motifs.
KW - DNA nanotechnology
KW - Molecular devices
KW - Synthetic biology
UR - https://www.scopus.com/pages/publications/62649162363
M3 - Conference contribution
AN - SCOPUS:62649162363
SN - 9783908158158
T3 - CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Mining Smartness from Nature
SP - 120
EP - 126
BT - CIMTEC 2008 - Proceedings of the 3rd International Conference on Smart Materials, Structures and Systems - Mining Smartness from Nature
T2 - 3rd International Conference on Smart Materials, Structures and Systems - Mining Smartness from Nature, CIMTEC 2008
Y2 - 8 June 2008 through 13 June 2008
ER -