TY - JOUR
T1 - Towards better mouse models
T2 - Enhanced genotypes, systemic phenotyping and envirotype modelling
AU - Beckers, Johannes
AU - Wurst, Wolfgang
AU - De Angelis, Martin Hrabé
N1 - Funding Information:
The authors are funded through the German Ministry of Science and Education and the European Commission (grant numbers: 01GS0850, LSHG-2006-037188, 211414, LSHG-CT-2006-518240, MRTN-CT-2006-035468).
PY - 2009/6
Y1 - 2009/6
N2 - The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
AB - The mouse is the leading mammalian model organism for basic genetic research and for studying human diseases. Coordinated international projects are currently in progress to generate a comprehensive map of mouse gene functions the first for any mammalian genome. There are still many challenges ahead to maximize the value of the mouse as a model, particularly for human disease. These involve generating mice that are better models of human diseases at the genotypic level, systemic (assessing all organ systems) and systematic (analysing all mouse lines) phenotyping of existing and new mouse mutant resources, and assessing the effects of the environment on phenotypes.
UR - http://www.scopus.com/inward/record.url?scp=67349229121&partnerID=8YFLogxK
U2 - 10.1038/nrg2578
DO - 10.1038/nrg2578
M3 - Review article
C2 - 19434078
AN - SCOPUS:67349229121
SN - 1471-0056
VL - 10
SP - 371
EP - 380
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 6
ER -