TY - JOUR
T1 - Towards an HBV cure
T2 - State-of-the-art and unresolved questions-report of the ANRS workshop on HBV cure
AU - Zeisel, Mirjam B.
AU - Lucifora, Julie
AU - Mason, William S.
AU - Sureau, Camille
AU - Beck, Jürgen
AU - Levrero, Massimo
AU - Kann, Michael
AU - Knolle, Percy A.
AU - Benkirane, Monsef
AU - Durantel, David
AU - Michel, Marie Louise
AU - Autran, Brigitte
AU - Cosset, François Loïc
AU - Strick-Marchand, Hélène
AU - Trépo, Christian
AU - Kao, Jia Horng
AU - Carrat, Fabrice
AU - Lacombe, Karine
AU - Schinazi, Raymond F.
AU - Barré-Sinoussi, Françoise
AU - Delfraissy, Jean François
AU - Zoulim, Fabien
PY - 2015/8/1
Y1 - 2015/8/1
N2 - HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-ofthe- art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.
AB - HBV infection is a major cause of liver cirrhosis and hepatocellular carcinoma. Although HBV infection can be efficiently prevented by vaccination, and treatments are available, to date there is no reliable cure for the >240 million individuals that are chronically infected worldwide. Current treatments can only achieve viral suppression, and lifelong therapy is needed in the majority of infected persons. In the framework of the French National Agency for Research on AIDS and Viral Hepatitis 'HBV Cure' programme, a scientific workshop was held in Paris in June 2014 to define the state-ofthe- art and unanswered questions regarding HBV pathobiology, and to develop a concerted strategy towards an HBV cure. This review summarises our current understanding of HBV host-interactions leading to viral persistence, as well as the roadblocks to be overcome to ultimately address unmet medical needs in the treatment of chronic HBV infection.
UR - http://www.scopus.com/inward/record.url?scp=84940459494&partnerID=8YFLogxK
U2 - 10.1136/gutjnl-2014-308943
DO - 10.1136/gutjnl-2014-308943
M3 - Article
C2 - 25670809
AN - SCOPUS:84940459494
SN - 0017-5749
VL - 64
SP - 1314
EP - 1326
JO - Gut
JF - Gut
IS - 8
ER -
