Towards a systems-level understanding of mitochondrial biology

Hilda Carolina Delgado de la Herran, Yiming Cheng, Fabiana Perocchi

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Human mitochondria are complex and highly dynamic biological systems, comprised of over a thousand parts and evolved to fully integrate into the specialized intracellular signaling networks and metabolic requirements of each cell and organ. Over the last two decades, several complementary, top-down computational and experimental approaches have been developed to identify, characterize and modulate the human mitochondrial system, demonstrating the power of integrating classical reductionist and discovery-driven analyses in order to de-orphanize hitherto unknown molecular components of mitochondrial machineries and pathways. To this goal, systematic, multiomics-based surveys of proteome composition, protein networks, and phenotype-to-pathway associations at the tissue, cell and organellar level have been largely exploited to predict the full complement of mitochondrial proteins and their functional interactions, therefore catalyzing data-driven hypotheses. Collectively, these multidisciplinary and integrative research approaches hold the potential to propel our understanding of mitochondrial biology and provide a systems-level framework to unraveling mitochondria-mediated and disease-spanning pathomechanisms.

Original languageEnglish
Article number102364
JournalCell Calcium
StatePublished - May 2021
Externally publishedYes


  • Functional associations
  • Integrative analyses
  • Mitochondrial system
  • Multiomics approaches


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