Toward whole-brain in vivo optoacoustic angiography of rodents: Modeling and experimental observations

Pavel Subochev, Ekaterina Smolina, Ekaterina Sergeeva, Mikhail Kirillin, Anna Orlova, Daria Kurakina, Daniil Emyanov, Daniel Razansky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We report on a comprehensive theoretical analysis of the optimal wavelengths for in vivo OA angiography in whole rodent brains. Governed by the competing processes of light attenuation through the brain tissues and OA signal generation due to absorption by blood, we identified three distinct spectral ranges centered around 580, 895 and 1100 nm optimally suited for imaging of vessels of different size and depth. The developed model was employed for numerical simulation of OA imaging of murine brain illustrating the effect of probing wavelength on visibility of the cerebral vasculature. In vivo imaging experiments further affirmed the capacity for whole-brain OA angiography in rodents at a wavelength of 1064nm.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy, OTS 2020
PublisherOptica Publishing Group (formerly OSA)
ISBN (Print)9781943580743
DOIs
StatePublished - 2020
Externally publishedYes
EventOptical Tomography and Spectroscopy, OTS 2020 - Washington, United States
Duration: 20 Apr 202023 Apr 2020

Publication series

NameOptics InfoBase Conference Papers
VolumePart F179-OTS-2020
ISSN (Electronic)2162-2701

Conference

ConferenceOptical Tomography and Spectroscopy, OTS 2020
Country/TerritoryUnited States
City Washington
Period20/04/2023/04/20

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