TY - JOUR
T1 - Toward one-pot lipase-catalyzed synthesis of poly(e-caprolactone) particles in aqueous dispersion
AU - Inprakhon, Pranee
AU - Panlawan, Pabhangkon
AU - Pongtharankul, Thunyarat
AU - Marie, Emmanuelle
AU - Wiemann, Lars O.
AU - Durand, Alain
AU - Sieber, Volker
N1 - Funding Information:
This research was supported by a European Marie Curie IIF scholarship (No. 301723 ), and by the Thailand Research Fund ( DBG5280003 )
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The preparation of polyester particles using enzyme-catalyzed (lipase from Candida antarctica B, CALB) ring-opening polymerization of e-caprolactone (e-CL) in aqueous dispersion was demonstrated for the first time. Immobilization of CALB enabled a significant increase of the number-average degree of polymerization of e-CL oligomers (up to 38) as compared to dissolved CALB (8 at the maximum). The nature and amount of lipase, as well as the nature of the support material were identified as key parameters controlling ring-opening polymerization of e-CL in aqueous dispersion. In addition, the involvement of solubilized monomers in polymerization elementary reactions was demonstrated and the consequences on oligomers average length were detailed. An overall mechanism of lipase-catalyzed e-CL polymerization in aqueous dispersion taking into account the colloidal nature of reaction medium was proposed on the basis of experimental results.
AB - The preparation of polyester particles using enzyme-catalyzed (lipase from Candida antarctica B, CALB) ring-opening polymerization of e-caprolactone (e-CL) in aqueous dispersion was demonstrated for the first time. Immobilization of CALB enabled a significant increase of the number-average degree of polymerization of e-CL oligomers (up to 38) as compared to dissolved CALB (8 at the maximum). The nature and amount of lipase, as well as the nature of the support material were identified as key parameters controlling ring-opening polymerization of e-CL in aqueous dispersion. In addition, the involvement of solubilized monomers in polymerization elementary reactions was demonstrated and the consequences on oligomers average length were detailed. An overall mechanism of lipase-catalyzed e-CL polymerization in aqueous dispersion taking into account the colloidal nature of reaction medium was proposed on the basis of experimental results.
KW - Aqueous dispersion
KW - Lipase
KW - Ring-opening polymerization
KW - e-caprolactone
UR - http://www.scopus.com/inward/record.url?scp=84885036026&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2013.09.011
DO - 10.1016/j.colsurfb.2013.09.011
M3 - Article
C2 - 24103504
AN - SCOPUS:84885036026
SN - 0927-7765
VL - 113
SP - 254
EP - 260
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -