TY - JOUR
T1 - Toward Functional Biointerfaces with Origami-on-a-Chip
AU - Ingar Romero, Alonso
AU - Jin, Qianru
AU - Parker, Kevin Kit
AU - Alexander, Joe
AU - Wolfrum, Bernhard
AU - Teshima, Tetsuhiko F.
N1 - Publisher Copyright:
© 2024 The Author(s). Advanced Intelligent Systems published by Wiley-VCH GmbH.
PY - 2024/9
Y1 - 2024/9
N2 - Studying the behavior of electroactive cells, such as firing dynamics and chemical secretion, is crucial for developing human disease models and therapeutics. Following the recent advances in cell culture technology, traditional monolayers are optimized to resemble more 3D, organ-like structures. The biological and electrochemical complexity of these structures requires devices with adaptive shapes and novel features, such as precise electrophysiological mapping and stimulation in the case of brain- and heart-derived tissues. However, conventional organ-on-chip platforms often fall short, as they do not recreate the native environment of the cells and lack the functional interfaces necessary for long-term monitoring. Origami-on-a-chip platforms offer a solution for this problem, as they can flexibly adapt to the structure of the desired biological sample and can be integrated with functional components enabled by chosen materials. In this review, the evolution of origami-on-a-chip biointerfaces is discussed, emphasizing folding stimuli, materials, and critical findings. In the prospects, microfluidic integration, functional tissue engineering scaffolds, and multi-organoid networks are included, allowing patient-specific diagnoses and therapies through computational and in vitro disease modeling.
AB - Studying the behavior of electroactive cells, such as firing dynamics and chemical secretion, is crucial for developing human disease models and therapeutics. Following the recent advances in cell culture technology, traditional monolayers are optimized to resemble more 3D, organ-like structures. The biological and electrochemical complexity of these structures requires devices with adaptive shapes and novel features, such as precise electrophysiological mapping and stimulation in the case of brain- and heart-derived tissues. However, conventional organ-on-chip platforms often fall short, as they do not recreate the native environment of the cells and lack the functional interfaces necessary for long-term monitoring. Origami-on-a-chip platforms offer a solution for this problem, as they can flexibly adapt to the structure of the desired biological sample and can be integrated with functional components enabled by chosen materials. In this review, the evolution of origami-on-a-chip biointerfaces is discussed, emphasizing folding stimuli, materials, and critical findings. In the prospects, microfluidic integration, functional tissue engineering scaffolds, and multi-organoid networks are included, allowing patient-specific diagnoses and therapies through computational and in vitro disease modeling.
KW - cell encapsulations
KW - organ on chips
KW - organoids
KW - self-foldings
KW - tissue engineerings
UR - http://www.scopus.com/inward/record.url?scp=85196322369&partnerID=8YFLogxK
U2 - 10.1002/aisy.202400055
DO - 10.1002/aisy.202400055
M3 - Review article
AN - SCOPUS:85196322369
SN - 2640-4567
VL - 6
JO - Advanced Intelligent Systems
JF - Advanced Intelligent Systems
IS - 9
M1 - 2400055
ER -