Total synthesis of meloscine by a [2+2]-photocycloaddition/ring-expansion route

Keyphrases

• Total Synthesis 100%
• Ring Expansion 100%
• Expansion Path 100%
• [2 + 2] Photocycloaddition 100%
• Enantioselectivity 75%
• Overall Yield 50%
• Retro 25%
• Substructure 25%
• Bicyclol 25%
• Stereochemistry 25%
• Cyclobutane 25%
• Enantioselective Synthesis 25%
• Reductive Amination 25%
• Simple Synthesis 25%
• Photochemical Transformation 25%
• Ring-closing Metathesis 25%
• Natural Product Synthesis 25%
• Complexing Agent 25%
• Vinyl Group 25%
• Johnson-Claisen Rearrangement 25%
• Domino Sequence 25%
• Pyrrolidine Ring 25%
• Selenylation 25%
• Ring Enlargement 25%
• Monoterpenoid Indole Alkaloids 25%
• Quaternary Stereocenters 25%
• Benzilic Acid Rearrangement 25%
• Heterocyclic Structure 25%

Chemistry

• Ring Expansion 100%
• Stereochemistry 50%
• Reductive Amination 50%
• Heterocyclic Compound 50%
• Ring Closing Metathesis 50%
• Wagner-Meerwein Rearrangement 50%
• Monoterpenoid Indole Alkaloid 50%
• Vinyl Group 50%
• Benzilic Acid Rearrangement 50%
• Claisen-Johnson Rearrangement 50%
• Cyclobutane 50%
• Pyrrolidine 50%
• Enantioselective Synthesis 50%
• Complex Formation 50%