To beat the heat-engineering of the most thermostable pyruvate decarboxylase to date

Samuel Sutiono, Katharina Satzinger, André Pick, Jörg Carsten, Volker Sieber

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Pyruvate decarboxylase (PDC) is a key enzyme for the production of ethanol at high temperatures and for cell-free butanol synthesis. Thermostable, organic solvent stable PDC was evolved from bacterial PDCs. The new variant shows >1500-fold-improved half-life at 75 °C and >5000-fold-increased half-life in the presence of 9 vol% butanol at 50 °C.

Original languageEnglish
Pages (from-to)29743-29746
Number of pages4
JournalRSC Advances
Volume9
Issue number51
DOIs
StatePublished - 2019

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