Titanium-catalyzed hydroamination of propargyl alcohol derivatives: Synthesis of 3-silyloxy-2-methylindoles via hydrohydrazination

Nicolle Schwarz, Karolin Alex, Iliyas Ali Sayyed, Vivek Khedkar, Annegret Tillack, Matthias Beller

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

A general method for the one-pot synthesis of substituted 3-(tert-butyldimethylsilyloxy)indoles via hydrohydrazination of alkynes and subsequent Fischer indole synthesis has been developed. For the first time titanium-catalyzed hydroaminations of propargyl alcohol derivatives are shown.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalSynlett
Issue number7
DOIs
StatePublished - 24 Apr 2007
Externally publishedYes

Keywords

  • Alkyne
  • Hydrazine
  • Hydroamination
  • Indole
  • Titanium

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