Tissue engineering scaffolds using superstructures

E. Wintermantel, J. Mayer, J. Blum, K. L. Eckert, P. Lüscher, M. Mathey

Research output: Contribution to journalArticlepeer-review

216 Scopus citations

Abstract

Here, scaffolds as cell and tissue carriers are approached from an engineering point of view, emphasizing material superstructuring in the design of supports. Superstructure engineering provides optimal spatial and nutritional conditions for cell maintenance by the arrangement of structural elements (e.g. pores or fibres) so as to vary the order of cell to cell contract. This approach is illustrated in the design of several scaffolds: knitted fabrics as three-dimensional superstructures for optimized osteosynthesis implants, a new injectable open porous implant system, an angiopolar non-degradable ceramic cell carrier, and an injectable or microsurgically implantable entangled carrier system. The implications for tissue engineering are discussed.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalBiomaterials
Volume17
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Cell carriers
  • Scaffold engineering
  • Superstructures
  • Tissue engineering

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