Tissue Engineering erektiler Nerven.

F. May; N. Weidner; K. Matiasek; M. Vroemen; T. Mrva; C. Caspers; J. Henke; T. Brill; A. Lehmer; A. Blesch; W. Erhardt; B. Gänsbacher; R. Hartung

doi:10.1007/s00120-004-0692-5

Tissue Engineering erektiler Nerven.

Translated title of the contribution: Tissue engineering of erectile nerves

F. May, N. Weidner, K. Matiasek, M. Vroemen, T. Mrva, C. Caspers, J. Henke, T. Brill, A. Lehmer, A. Blesch, W. Erhardt, B. Gänsbacher, R. Hartung

Chair of Experimental Oncology and Therapy Research

Technical University of Munich

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Dissection of the cavernous nerves eliminates spontaneous erections and may lead to irreversible erectile dysfunction due to degeneration of cavernous tissue. Novel procedures to reconstruct penile innervation include cavernous nerve interposition grafting and neurotrophic treatments to revitalize penile neural input, evaluated thus far in various preclinical models of cavernous nerve injury. Schwann cells crucially contribute to successful axonal regeneration by mechanical and paracrine mechanisms in the injured nerve, and Schwann cells seeded into guidance channels have been successfully employed to support regeneration in animal models of cavernous nerve injury. Gene therapy, tissue engineering, and reconstructive techniques have been combined to deliver neurotrophic factors and recover erectile function.

Translated title of the contribution	Tissue engineering of erectile nerves
Original language	German
Pages (from-to)	1242-1248
Number of pages	7
Journal	Urologe - Ausgabe A
Volume	43
Issue number	10
DOIs	https://doi.org/10.1007/s00120-004-0692-5
State	Published - Oct 2004

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title = "Tissue Engineering erektiler Nerven.",

abstract = "Dissection of the cavernous nerves eliminates spontaneous erections and may lead to irreversible erectile dysfunction due to degeneration of cavernous tissue. Novel procedures to reconstruct penile innervation include cavernous nerve interposition grafting and neurotrophic treatments to revitalize penile neural input, evaluated thus far in various preclinical models of cavernous nerve injury. Schwann cells crucially contribute to successful axonal regeneration by mechanical and paracrine mechanisms in the injured nerve, and Schwann cells seeded into guidance channels have been successfully employed to support regeneration in animal models of cavernous nerve injury. Gene therapy, tissue engineering, and reconstructive techniques have been combined to deliver neurotrophic factors and recover erectile function.",

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T1 - Tissue Engineering erektiler Nerven.

AU - May, F.

AU - Weidner, N.

AU - Matiasek, K.

AU - Vroemen, M.

AU - Mrva, T.

AU - Caspers, C.

AU - Henke, J.

AU - Brill, T.

AU - Lehmer, A.

AU - Blesch, A.

AU - Erhardt, W.

AU - Gänsbacher, B.

AU - Hartung, R.

PY - 2004/10

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N2 - Dissection of the cavernous nerves eliminates spontaneous erections and may lead to irreversible erectile dysfunction due to degeneration of cavernous tissue. Novel procedures to reconstruct penile innervation include cavernous nerve interposition grafting and neurotrophic treatments to revitalize penile neural input, evaluated thus far in various preclinical models of cavernous nerve injury. Schwann cells crucially contribute to successful axonal regeneration by mechanical and paracrine mechanisms in the injured nerve, and Schwann cells seeded into guidance channels have been successfully employed to support regeneration in animal models of cavernous nerve injury. Gene therapy, tissue engineering, and reconstructive techniques have been combined to deliver neurotrophic factors and recover erectile function.

AB - Dissection of the cavernous nerves eliminates spontaneous erections and may lead to irreversible erectile dysfunction due to degeneration of cavernous tissue. Novel procedures to reconstruct penile innervation include cavernous nerve interposition grafting and neurotrophic treatments to revitalize penile neural input, evaluated thus far in various preclinical models of cavernous nerve injury. Schwann cells crucially contribute to successful axonal regeneration by mechanical and paracrine mechanisms in the injured nerve, and Schwann cells seeded into guidance channels have been successfully employed to support regeneration in animal models of cavernous nerve injury. Gene therapy, tissue engineering, and reconstructive techniques have been combined to deliver neurotrophic factors and recover erectile function.

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M3 - Übersichtsartikel

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Tissue Engineering erektiler Nerven.

Abstract

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