Time-resolved flow measurement in the isolated rat heart: Characterization of left coronary artery stenosis

Sascha Köhler, Karl Heinz Hiller, Peter M. Jakob, Wolfgang R. Bauer, Axel Haase

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The investigation of flow behavior in coronary arteries is of great importance for an understanding of heart failure and heart regulation mechanisms. The purpose of the present study was to demonstrate that flow velocity can be quantified in the coronary arteries of the isolated rat heart with high-resolution phase contrast MRI. A phase contrast cine-FLASH imaging sequence was used for flow quantification with an in-plane resolution of 70 μm and a slice thickness of 500 μm. With time-resolved measurements, coronary flow over the heart cycle was analyzed. Furthermore, the flow behavior in coronary stenosis was investigated and the degree of stenosis was quantified with MR phase contrast imaging. To achieve the required spatial resolution and a satisfactory signal-to-noise ratio, the experiments were performed at 11.75 T.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalMagnetic Resonance in Medicine
Volume50
Issue number3
DOIs
StatePublished - 1 Sep 2003
Externally publishedYes

Keywords

  • Coronary flow velocity
  • Isolated rat heart
  • MRI
  • Phase contrast
  • Stenosis

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