Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with 18F-FDG PET applying fully integrated PET/MRI

I. Einspieler; M. Henninger; V. Mergen; H. Wendorff; B. Haller; M. Eiber; E. J. Rummeny; M. Schwaiger; P. Moog; K. Thürmel

doi:10.1016/j.crad.2019.04.012

Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with ¹⁸F-FDG PET applying fully integrated PET/MRI

I. Einspieler
, M. Henninger
, V. Mergen
, H. Wendorff
, B. Haller
, M. Eiber
, E. J. Rummeny
, M. Schwaiger
, P. Moog
, K. Thürmel

Technical University of Munich
Klinikum der Universität Regensburg und Medizinische Fakultät

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

AIM: To evaluate the feasibility of T1-weighted (T1W) three-dimensional (3D) fat saturated Cartesian volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) sequence for the diagnosis of aortitis in patients with suspected large vessel vasculitis (LVV) applying fully integrated 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron-emission tomography (PET)/MRI. MATERIAL AND METHODS: Fourteen patients with aortitis and 14 patients with a negative study for aortitis using ¹⁸F-FDG PET as the standard of reference for the evaluation of inflammatory aortic involvement were included retrospectively. All patients were imaged at 3 T using T1W VIBE pre- and post-contrast. Four aortic segments were evaluated for image quality (IQ), diagnostic confidence (DC), and the degree of inflammatory activity (IA) using a Likert scale. Binomial and generalised estimating equation model tests were used to assess the diagnostic performance of T1W VIBE. Cohen's k was applied to test for interobserver reproducibility with respect to IA. Spearman's rank correlation coefficient was calculated to examine correlations between IQ, DC, IA, and PET results. RESULTS: On a patient- and segment-based analysis, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 85.7% and 59.8%, 100% and 100%, 100% and 100%, 87.5% and 68%, and 92.9% and 82.1%, respectively. IQ and DC were acceptable to good in all examinations and substantial interobserver agreement was observed for IA (Cohen's k = 0.69). IQ and DC as well as IA and ¹⁸F-FDG vessel wall uptake were significantly correlated (r=0.763 and 0.679, respectively; p<0.0001). CONCLUSION: T1W 3D fat saturated VIBE MRI allows diagnosis of aortitis and may aid in the management of patients with suspected LVV.

Original language	English
Pages (from-to)	731.e11-731.e19
Journal	Clinical Radiology
Volume	74
Issue number	9
DOIs	https://doi.org/10.1016/j.crad.2019.04.012
State	Published - Sep 2019

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Einspieler, I., Henninger, M., Mergen, V., Wendorff, H., Haller, B., Eiber, M., Rummeny, E. J., Schwaiger, M., Moog, P., & Thürmel, K. (2019). Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with ¹⁸F-FDG PET applying fully integrated PET/MRI. Clinical Radiology, 74(9), 731.e11-731.e19. https://doi.org/10.1016/j.crad.2019.04.012

Einspieler, I. ; Henninger, M. ; Mergen, V. et al. / Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis : a comparative study with ¹⁸F-FDG PET applying fully integrated PET/MRI. In: Clinical Radiology. 2019 ; Vol. 74, No. 9. pp. 731.e11-731.e19.

@article{b7d4c48a3ba5483aa39909916c4aa300,

title = "Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with 18F-FDG PET applying fully integrated PET/MRI",

abstract = "AIM: To evaluate the feasibility of T1-weighted (T1W) three-dimensional (3D) fat saturated Cartesian volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) sequence for the diagnosis of aortitis in patients with suspected large vessel vasculitis (LVV) applying fully integrated 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron-emission tomography (PET)/MRI. MATERIAL AND METHODS: Fourteen patients with aortitis and 14 patients with a negative study for aortitis using 18F-FDG PET as the standard of reference for the evaluation of inflammatory aortic involvement were included retrospectively. All patients were imaged at 3 T using T1W VIBE pre- and post-contrast. Four aortic segments were evaluated for image quality (IQ), diagnostic confidence (DC), and the degree of inflammatory activity (IA) using a Likert scale. Binomial and generalised estimating equation model tests were used to assess the diagnostic performance of T1W VIBE. Cohen's k was applied to test for interobserver reproducibility with respect to IA. Spearman's rank correlation coefficient was calculated to examine correlations between IQ, DC, IA, and PET results. RESULTS: On a patient- and segment-based analysis, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 85.7\% and 59.8\%, 100\% and 100\%, 100\% and 100\%, 87.5\% and 68\%, and 92.9\% and 82.1\%, respectively. IQ and DC were acceptable to good in all examinations and substantial interobserver agreement was observed for IA (Cohen's k = 0.69). IQ and DC as well as IA and 18F-FDG vessel wall uptake were significantly correlated (r=0.763 and 0.679, respectively; p<0.0001). CONCLUSION: T1W 3D fat saturated VIBE MRI allows diagnosis of aortitis and may aid in the management of patients with suspected LVV.",

author = "I. Einspieler and M. Henninger and V. Mergen and H. Wendorff and B. Haller and M. Eiber and Rummeny, \{E. J.\} and M. Schwaiger and P. Moog and K. Th{\"u}rmel",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal College of Radiologists",

year = "2019",

month = sep,

doi = "10.1016/j.crad.2019.04.012",

language = "English",

volume = "74",

pages = "731.e11--731.e19",

journal = "Clinical Radiology",

issn = "0009-9260",

publisher = "W.B. Saunders Ltd",

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}

Einspieler, I, Henninger, M, Mergen, V, Wendorff, H, Haller, B, Eiber, M , Rummeny, EJ , Schwaiger, M, Moog, P & Thürmel, K 2019, 'Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with ¹⁸F-FDG PET applying fully integrated PET/MRI', Clinical Radiology, vol. 74, no. 9, pp. 731.e11-731.e19. https://doi.org/10.1016/j.crad.2019.04.012

Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis: a comparative study with ¹⁸F-FDG PET applying fully integrated PET/MRI. / Einspieler, I.; Henninger, M.; Mergen, V. et al.
In: Clinical Radiology, Vol. 74, No. 9, 09.2019, p. 731.e11-731.e19.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Three-dimensional fat-saturated T1-weighted Cartesian volumetric interpolated breath-hold examination (VIBE) for the diagnosis of aortitis in patients with suspected large vessel vasculitis

T2 - a comparative study with 18F-FDG PET applying fully integrated PET/MRI

AU - Einspieler, I.

AU - Henninger, M.

AU - Mergen, V.

AU - Wendorff, H.

AU - Haller, B.

AU - Eiber, M.

AU - Rummeny, E. J.

AU - Schwaiger, M.

AU - Moog, P.

AU - Thürmel, K.

PY - 2019/9

Y1 - 2019/9

N2 - AIM: To evaluate the feasibility of T1-weighted (T1W) three-dimensional (3D) fat saturated Cartesian volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) sequence for the diagnosis of aortitis in patients with suspected large vessel vasculitis (LVV) applying fully integrated 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron-emission tomography (PET)/MRI. MATERIAL AND METHODS: Fourteen patients with aortitis and 14 patients with a negative study for aortitis using 18F-FDG PET as the standard of reference for the evaluation of inflammatory aortic involvement were included retrospectively. All patients were imaged at 3 T using T1W VIBE pre- and post-contrast. Four aortic segments were evaluated for image quality (IQ), diagnostic confidence (DC), and the degree of inflammatory activity (IA) using a Likert scale. Binomial and generalised estimating equation model tests were used to assess the diagnostic performance of T1W VIBE. Cohen's k was applied to test for interobserver reproducibility with respect to IA. Spearman's rank correlation coefficient was calculated to examine correlations between IQ, DC, IA, and PET results. RESULTS: On a patient- and segment-based analysis, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 85.7% and 59.8%, 100% and 100%, 100% and 100%, 87.5% and 68%, and 92.9% and 82.1%, respectively. IQ and DC were acceptable to good in all examinations and substantial interobserver agreement was observed for IA (Cohen's k = 0.69). IQ and DC as well as IA and 18F-FDG vessel wall uptake were significantly correlated (r=0.763 and 0.679, respectively; p<0.0001). CONCLUSION: T1W 3D fat saturated VIBE MRI allows diagnosis of aortitis and may aid in the management of patients with suspected LVV.

AB - AIM: To evaluate the feasibility of T1-weighted (T1W) three-dimensional (3D) fat saturated Cartesian volumetric interpolated breath-hold examination (VIBE) magnetic resonance imaging (MRI) sequence for the diagnosis of aortitis in patients with suspected large vessel vasculitis (LVV) applying fully integrated 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron-emission tomography (PET)/MRI. MATERIAL AND METHODS: Fourteen patients with aortitis and 14 patients with a negative study for aortitis using 18F-FDG PET as the standard of reference for the evaluation of inflammatory aortic involvement were included retrospectively. All patients were imaged at 3 T using T1W VIBE pre- and post-contrast. Four aortic segments were evaluated for image quality (IQ), diagnostic confidence (DC), and the degree of inflammatory activity (IA) using a Likert scale. Binomial and generalised estimating equation model tests were used to assess the diagnostic performance of T1W VIBE. Cohen's k was applied to test for interobserver reproducibility with respect to IA. Spearman's rank correlation coefficient was calculated to examine correlations between IQ, DC, IA, and PET results. RESULTS: On a patient- and segment-based analysis, sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 85.7% and 59.8%, 100% and 100%, 100% and 100%, 87.5% and 68%, and 92.9% and 82.1%, respectively. IQ and DC were acceptable to good in all examinations and substantial interobserver agreement was observed for IA (Cohen's k = 0.69). IQ and DC as well as IA and 18F-FDG vessel wall uptake were significantly correlated (r=0.763 and 0.679, respectively; p<0.0001). CONCLUSION: T1W 3D fat saturated VIBE MRI allows diagnosis of aortitis and may aid in the management of patients with suspected LVV.

UR - https://www.scopus.com/pages/publications/85065906000

U2 - 10.1016/j.crad.2019.04.012

DO - 10.1016/j.crad.2019.04.012

M3 - Article

C2 - 31130228

AN - SCOPUS:85065906000

SN - 0009-9260

VL - 74

SP - 731.e11-731.e19

JO - Clinical Radiology

JF - Clinical Radiology

IS - 9

ER -