TY - JOUR
T1 - Three-dimensional assessment of myocardial oxidative metabolism
T2 - A new approach for regional determination of PET-derived carbon-11-acetate kinetics
AU - Kotzerke, J.
AU - Hicks, R. J.
AU - Wolfe, E.
AU - Herman, W. H.
AU - Molina, E.
AU - Kuhl, D. E.
AU - Schwaiger, M.
PY - 1990
Y1 - 1990
N2 - We have developed a new analysis algorithm which generates polar coordinate maps of myocardial carbon-11-(11C) acetate kinetics. In 10 normal subjects (n = 20 studies), myocardial 11C clearance rate constants (k) averaged 0.057 ± 0.009 (per minute). Regional k-values varied only 10.6 ± 2.4% in the normal left ventricle. However, there was a small but significant segmental variation with increased 11C clearance in the septal, anterior, and basal regions (p < 0.05). Since 11C clearance rates reflect tri-carboxylic acid cycle flux, these results suggest that myocardial oxidative metabolism is relatively homogeneous in the normal human heart at rest with minor regional variations, which possibly reflect varying regional wall stresses or substrate utilization. The proposed approach provides three-dimensional evaluation of regional oxidative metabolism which will permit characterization of the location, extent, and severity of myocardial disease.
AB - We have developed a new analysis algorithm which generates polar coordinate maps of myocardial carbon-11-(11C) acetate kinetics. In 10 normal subjects (n = 20 studies), myocardial 11C clearance rate constants (k) averaged 0.057 ± 0.009 (per minute). Regional k-values varied only 10.6 ± 2.4% in the normal left ventricle. However, there was a small but significant segmental variation with increased 11C clearance in the septal, anterior, and basal regions (p < 0.05). Since 11C clearance rates reflect tri-carboxylic acid cycle flux, these results suggest that myocardial oxidative metabolism is relatively homogeneous in the normal human heart at rest with minor regional variations, which possibly reflect varying regional wall stresses or substrate utilization. The proposed approach provides three-dimensional evaluation of regional oxidative metabolism which will permit characterization of the location, extent, and severity of myocardial disease.
UR - http://www.scopus.com/inward/record.url?scp=0025131825&partnerID=8YFLogxK
M3 - Article
C2 - 2231005
AN - SCOPUS:0025131825
SN - 0161-5505
VL - 31
SP - 1876
EP - 1883
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 11
ER -