Thogoto virus lacking interferon-antagonistic protein ML is strongly attenuated in newborn Mx1-positive but not Mx1-negative mice

Andreas Pichlmair, Johanna Buse, Stephanie Jennings, Otto Haller, Georg Kochs, Peter Staeheli

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The Thogoto virus ML protein snppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating that enhanced interferon synthesis is protective only if appropriate antiviral effector molecules are present. Our study shows that the virulence-enhancing effects of some viral interferon antagonists may escape detection in conventional animal models.

Original languageEnglish
Pages (from-to)11422-11424
Number of pages3
JournalJournal of Virology
Volume78
Issue number20
DOIs
StatePublished - Oct 2004
Externally publishedYes

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