Thiolato gold(i) complexes containing water-soluble phosphane ligands: A characterization of their chemical and biological properties

Elena Vergara; Elena Cerrada; Catherine Clavel; Angela Casini; Mariano Laguna

doi:10.1039/c1dt10892a

Thiolato gold(i) complexes containing water-soluble phosphane ligands: A characterization of their chemical and biological properties

Elena Vergara, Elena Cerrada, Catherine Clavel, Angela Casini, Mariano Laguna

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A series of thiolate gold(i) derivatives bearing water soluble phosphanes - namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) - is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe ₂pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.

Original language	English
Pages (from-to)	10927-10935
Number of pages	9
Journal	Dalton Transactions
Volume	40
Issue number	41
DOIs	https://doi.org/10.1039/c1dt10892a
State	Published - 7 Nov 2011
Externally published	Yes

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title = "Thiolato gold(i) complexes containing water-soluble phosphane ligands: A characterization of their chemical and biological properties",

abstract = "A series of thiolate gold(i) derivatives bearing water soluble phosphanes - namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) - is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe 2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.",

author = "Elena Vergara and Elena Cerrada and Catherine Clavel and Angela Casini and Mariano Laguna",

year = "2011",

month = nov,

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doi = "10.1039/c1dt10892a",

language = "English",

volume = "40",

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journal = "Dalton Transactions",

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TY - JOUR

T1 - Thiolato gold(i) complexes containing water-soluble phosphane ligands

T2 - A characterization of their chemical and biological properties

AU - Vergara, Elena

AU - Cerrada, Elena

AU - Clavel, Catherine

AU - Casini, Angela

AU - Laguna, Mariano

PY - 2011/11/7

Y1 - 2011/11/7

N2 - A series of thiolate gold(i) derivatives bearing water soluble phosphanes - namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) - is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe 2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.

AB - A series of thiolate gold(i) derivatives bearing water soluble phosphanes - namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) - is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe 2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.

UR - https://www.scopus.com/pages/publications/80053986710

U2 - 10.1039/c1dt10892a

DO - 10.1039/c1dt10892a

M3 - Article

C2 - 21904768

AN - SCOPUS:80053986710

SN - 1477-9226

VL - 40

SP - 10927

EP - 10935

JO - Dalton Transactions

JF - Dalton Transactions

IS - 41

ER -

Thiolato gold(i) complexes containing water-soluble phosphane ligands: A characterization of their chemical and biological properties

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