Abstract
According to the current S2k guideline Gastroesophageal Reflux Disease (GERD) of 05/2014, an empirical proton pump inhibitor (PPI) therapy in double standard dose (e.asg. Pantoprazole 40asmg 2as×/day) is recommended for the extraesophageal GERD manifestation (e.asg. with formation of a contact granuloma, CG) for 8 weeks. However, valid study data don't exist. In a prospective study from 05.2015 to 12.2019 39 patients consecutively randomized with endoscopically proven KG received PPIs in single (1as×asPPI, nas=as22) or double standard dose (2as×asPPI, nas=as17) for 8 weeks. A possible gastrolaryngeal reflux as well as throat sensations, a tendency to clear the throat or a hoarseness were recorded at first presentation and at control after 4 months.This was archieved by videolaryngostroboscopy to detect hoarseness and to assess the development of the granuloma (progression, constant, remission <as50as%, >as50as% or complete). The two groups were compared. The granuloma disappeared or regressed in 40as% of the cases with 1as×asPPIs and in 77as% of the cases with 2as×asPPIs (pas<as0.05) after therapy. At the control appointment 23as% of the patients with 1as×asPPIs were completely symptom-free and 77as% of the patients with 2as×asPPIs. Throat sensation was the most frequent symptom at first presentation with 64as%. In the control group after PPI therapy in single or double standard dose, throat sensations were only detectable in 33as% and 15as% in case of granuloma remission. However, if the granuloma was persistent, the symptoms could hardly be influenced. The therapy of a KG with PPIs in double standard dose is more effective than in single standard dose. These results must be confirmed on a larger collective.
Translated title of the contribution | Therapeutic success of proton pump inhibitors in the therapy of contact granulomas |
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Original language | German |
Pages (from-to) | 202-206 |
Number of pages | 5 |
Journal | Laryngo- Rhino- Otologie |
Volume | 100 |
Issue number | 3 |
DOIs | |
State | Published - 1 Mar 2021 |