Therapieerfolg von Protonenpumpeninhibitoren bei der Therapie von Kontaktgranulomen

Translated title of the contribution: Therapeutic success of proton pump inhibitors in the therapy of contact granulomas

Adrienne Heyduck, Anja Pickhard, Arno Olthoff, Thomas Hoffmann, Rudolf Reiter

Research output: Contribution to journalArticlepeer-review

Abstract

According to the current S2k guideline Gastroesophageal Reflux Disease (GERD) of 05/2014, an empirical proton pump inhibitor (PPI) therapy in double standard dose (e.asg. Pantoprazole 40asmg 2as×/day) is recommended for the extraesophageal GERD manifestation (e.asg. with formation of a contact granuloma, CG) for 8 weeks. However, valid study data don't exist. In a prospective study from 05.2015 to 12.2019 39 patients consecutively randomized with endoscopically proven KG received PPIs in single (1as×asPPI, nas=as22) or double standard dose (2as×asPPI, nas=as17) for 8 weeks. A possible gastrolaryngeal reflux as well as throat sensations, a tendency to clear the throat or a hoarseness were recorded at first presentation and at control after 4 months.This was archieved by videolaryngostroboscopy to detect hoarseness and to assess the development of the granuloma (progression, constant, remission <as50as%, >as50as% or complete). The two groups were compared. The granuloma disappeared or regressed in 40as% of the cases with 1as×asPPIs and in 77as% of the cases with 2as×asPPIs (pas<as0.05) after therapy. At the control appointment 23as% of the patients with 1as×asPPIs were completely symptom-free and 77as% of the patients with 2as×asPPIs. Throat sensation was the most frequent symptom at first presentation with 64as%. In the control group after PPI therapy in single or double standard dose, throat sensations were only detectable in 33as% and 15as% in case of granuloma remission. However, if the granuloma was persistent, the symptoms could hardly be influenced. The therapy of a KG with PPIs in double standard dose is more effective than in single standard dose. These results must be confirmed on a larger collective.

Translated title of the contributionTherapeutic success of proton pump inhibitors in the therapy of contact granulomas
Original languageGerman
Pages (from-to)202-206
Number of pages5
JournalLaryngo- Rhino- Otologie
Volume100
Issue number3
DOIs
StatePublished - 1 Mar 2021

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