Therapie entzündeter Haut: Es muss nicht immer Kortison sein

This paper deals with corticoid alternatives such as calcineurin inhibitors, sulfonated shale oils, ultraviolet light and climatotherapy which are discussed in detail. Topical calcineurin inhibitors can be understood as immunosuppressants which inhibit T-lymphocyte activation and prevent the release of pro-in?ammatory cytokines. The in?ammation inhibition of sulfonated shale oils is to be based on an inhibition of 5-lipoxygenase as well as 5-hydroxyeicosatetraenoic acid and leukotriene B4. The rationale for the use of a UV light treatment is its anti-in?ammatory effect on antigen-presenting Langerhans cells, infltrating T cells, and proin?ammatory cytokines. A climatherapy in the high mountain range above 1500 meters above sea level is - among other things - a freedom from house dust mites allergens. Other potent allergens (e.g., birch and grass pollen, mold spores) are signifcantly reduced in concentration as well as in the duration of their occurrence.