Therapeutic efficacy of ferrofluid bound anticancer agent

Ch Alexiou; W. Arnold; P. Hulin; R. Klein; A. Schmidt; Ch Bergemannand; F. G. Parak

doi:10.22364/mhd.37.3.16

Therapeutic efficacy of ferrofluid bound anticancer agent

Ch Alexiou, W. Arnold, P. Hulin, R. Klein, A. Schmidt, Ch Bergemannand, F. G. Parak

Chair of Biomedical Physics

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ferrofluids coated with starch polymers can be used as biocompatible carriers in a new field of locoregional tumor therapy called " magnetic drug targeting". Bound to medical drugs, such magnetic nanoparticles can be enriched in a desired body compartment using an external magnetic field. In the present study, we confirm the concentration of ferrofluids in VX2 squamous cell carcinoma tissue of the rabbit using histological investigations and MR imaging. The therapeutic efficacy of "magnetic drug targeting" was studied using the rabbit VX2 squamous cell carcinoma model. Mitoxantrone coupled ferrofluids were injected intraarterially into the artery supplying the tumor (femoral artery). The magnetic field (1.7 Tesla) was focused to the tumor placed at the medial portion of the hind limb of New Zealand White rabbits. Complete tumor remissions could be seen without any negative side effects by using only 20% of the normal systemic dosage of the chemotherapeutic agent mitoxantrone.

Original language	English
Pages (from-to)	318-322
Number of pages	5
Journal	Magnetohydrodynamics
Volume	37
Issue number	3
DOIs	https://doi.org/10.22364/mhd.37.3.16
State	Published - 2001

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AU - Alexiou, Ch

AU - Arnold, W.

AU - Hulin, P.

AU - Klein, R.

AU - Schmidt, A.

AU - Bergemannand, Ch

AU - Parak, F. G.

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Therapeutic efficacy of ferrofluid bound anticancer agent

Abstract

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