Theoretical foundation and experimental proof of the accumulating transfer of tritium from water into DNA and other biomolecules in vitro and in vivo.

Heisenberg's uncertainty principle, which describes a fundamental property of matter, predicts the light hydrogen isotope to prefer the strong hydrogen bridge positions (with large local uncertainty). In contrast, the heavy hydrogen isotope tritium originally localized in water, should finally be found in the exchangeable hydrogen bridge positions of proteins, carbohydrates and nucleotides which are definitely less strong than those of water. The fractionation factor of tritium and protium measured between water and DNA as well as the mixture of biomolecules of liver confirm this conclusion and show in addition, a tritum accumulation also in the hydration sheets of the biomolecules. Furthermore, the larger intrinsic rate of natural increase of tritium than of hydrogen in tissue solids of growing maize and barley confirm the accumulating tritium transfer from water to biomolecules taking place in vivo.