The use of screen printed electrodes for the sensing of cell responses

Martin Brischwein, Sigrun Herrmann, Winfried Vonau, Frank Berthold, Helmut Grothe, Elena R. Motrescu, Bernhard Wolf

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

11 Scopus citations

Abstract

Impedance sensors in thick film technology have been tested as a tool for testing cell-mediated effects. The screen printed Pt electrodes have a width of 250-400 μm. Electrodes and the surrounding ceramic chip substrate could be homogeneously grown with L-929 and Hela cells. The performance of a screen printed interdigitated electrode structure (IDES) was compared with that of thin film structures with the same layout geometry. The thick film impedance sensors allowed to correctly record the morphological response of confluent Hela cell layers to stimulation with histamine. A thick film conductivity sensor also revealed impedance values which were dependent on cell growth on the electrode surface, even at a very low frequency range of ≈1 Hz.

Original languageEnglish
Title of host publicationIEEE AFRICON 2007
DOIs
StatePublished - 2007
EventIEEE AFRICON 2007 - Windhoek, South Africa
Duration: 26 Sep 200728 Sep 2007

Publication series

NameIEEE AFRICON Conference

Conference

ConferenceIEEE AFRICON 2007
Country/TerritorySouth Africa
CityWindhoek
Period26/09/0728/09/07

Keywords

  • Cell based assay
  • Electric impedance
  • Electrochemical impedance spectroscopy
  • Screen printed electrodes

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