The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews

B. N. Ames; P. Boyle; J. Douli; C. L. Galli; H. Greim; Y. Hayashi; R. N. Hill; R. D. Kimbrough; D. Krewski; R. Kroes; R. R. Monson; I. C. Munro; M. F. Rajewsky; R. J. Scheuplein; T. Sugimura; J. A. Swenberg; C. C. Travis; J. Whysner; G. M. Williams

doi:10.1016/s0163-7258(96)90014-5

The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews

B. N. Ames, P. Boyle, J. Douli, C. L. Galli, H. Greim, Y. Hayashi, R. N. Hill, R. D. Kimbrough, D. Krewski, R. Kroes, R. R. Monson, I. C. Munro, M. F. Rajewsky, R. J. Scheuplein, T. Sugimura, J. A. Swenberg, C. C. Travis, J. Whysner, G. M. Williams

Institute For Cancer Prevention

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in-depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Pharmacology and Therapeutics
Volume	71
Issue number	1-2
DOIs	https://doi.org/10.1016/s0163-7258(96)90014-5
State	Published - 1996
Externally published	Yes

Keywords

cancer mechanism
DNA reactivity
epigenetic effects
risk assessment
threshold

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/s0163-7258(96)90014-5

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Ames, B. N., Boyle, P., Douli, J., Galli, C. L., Greim, H., Hayashi, Y., Hill, R. N., Kimbrough, R. D., Krewski, D., Kroes, R., Monson, R. R., Munro, I. C., Rajewsky, M. F., Scheuplein, R. J., Sugimura, T., Swenberg, J. A., Travis, C. C., Whysner, J., & Williams, G. M. (1996). The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews. Pharmacology and Therapeutics, 71(1-2), 1-5. https://doi.org/10.1016/s0163-7258(96)90014-5

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title = "The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews",

abstract = "The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in-depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.",

keywords = "cancer mechanism, DNA reactivity, epigenetic effects, risk assessment, threshold",

author = "Ames, {B. N.} and P. Boyle and J. Douli and Galli, {C. L.} and H. Greim and Y. Hayashi and Hill, {R. N.} and Kimbrough, {R. D.} and D. Krewski and R. Kroes and Monson, {R. R.} and Munro, {I. C.} and Rajewsky, {M. F.} and Scheuplein, {R. J.} and T. Sugimura and Swenberg, {J. A.} and Travis, {C. C.} and J. Whysner and Williams, {G. M.}",

year = "1996",

doi = "10.1016/s0163-7258(96)90014-5",

language = "English",

volume = "71",

pages = "1--5",

journal = "Pharmacology and Therapeutics",

issn = "0163-7258",

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Ames, BN, Boyle, P, Douli, J, Galli, CL, Greim, H, Hayashi, Y, Hill, RN, Kimbrough, RD, Krewski, D, Kroes, R, Monson, RR, Munro, IC, Rajewsky, MF, Scheuplein, RJ, Sugimura, T, Swenberg, JA, Travis, CC, Whysner, J & Williams, GM 1996, 'The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews', Pharmacology and Therapeutics, vol. 71, no. 1-2, pp. 1-5. https://doi.org/10.1016/s0163-7258(96)90014-5

TY - JOUR

T1 - The use of mechanistic data in the risk assessments of ten chemicals

T2 - An introduction to the chemical-specific reviews

AU - Ames, B. N.

AU - Boyle, P.

AU - Douli, J.

AU - Galli, C. L.

AU - Greim, H.

AU - Hayashi, Y.

AU - Hill, R. N.

AU - Kimbrough, R. D.

AU - Krewski, D.

AU - Kroes, R.

AU - Monson, R. R.

AU - Munro, I. C.

AU - Rajewsky, M. F.

AU - Scheuplein, R. J.

AU - Sugimura, T.

AU - Swenberg, J. A.

AU - Travis, C. C.

AU - Whysner, J.

AU - Williams, G. M.

PY - 1996

Y1 - 1996

N2 - The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in-depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.

AB - The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in-depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.

KW - cancer mechanism

KW - DNA reactivity

KW - epigenetic effects

KW - risk assessment

KW - threshold

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DO - 10.1016/s0163-7258(96)90014-5

M3 - Short survey

C2 - 8910946

AN - SCOPUS:0029780851

SN - 0163-7258

VL - 71

SP - 1

EP - 5

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 1-2

ER -

The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews

Abstract

Keywords

UN SDGs

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