The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews

B. N. Ames, P. Boyle, J. Douli, C. L. Galli, H. Greim, Y. Hayashi, R. N. Hill, R. D. Kimbrough, D. Krewski, R. Kroes, R. R. Monson, I. C. Munro, M. F. Rajewsky, R. J. Scheuplein, T. Sugimura, J. A. Swenberg, C. C. Travis, J. Whysner, G. M. Williams

Research output: Contribution to journalShort surveypeer-review

11 Scopus citations

Abstract

The International Expert Panel on Carcinogen Risk Assessment of the American Health Foundation has planned, directed and reviewed in-depth analyses of mechanistic data for 10 rodent carcinogens. The purpose of this review was to illustrate the use of mechanistic data in carcinogen risk assessment. The mechanisms by which a chemical produces cancer in rodents provided important information for determining whether or not humans would be at risk at low exposure levels. For epigenetic (non-DNA-reactive) carcinogens, current exposure levels for these chemicals below a threshold do not pose a risk. For DNA-reactive agents at sufficient exposures, humans would be expected to be at risk. However, protective mechanisms may lower the expected risk, especially at low-level exposures.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalPharmacology and Therapeutics
Volume71
Issue number1-2
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • DNA reactivity
  • cancer mechanism
  • epigenetic effects
  • risk assessment
  • threshold

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