The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy

Florian Heinen; Kaat Desloovere; A. Sebastian Schroeder; Steffen Berweck; Ingo Borggraefe; Anya van Campenhout; Guro L. Andersen; Resa Aydin; Jules G. Becher; Günther Bernert; Ignacio Martinez Caballero; Lucinda Carr; Emmanuelle Chaleat Valayer; Maria Teresa Desiato; Charlie Fairhurst; Paul Filipetti; Ralph Ingo Hassink; Ulf Hustedt; Marek Jozwiak; Serdar Ibrahim Kocer; Elisabeth Kolanowski; Ingeborg Krägeloh-Mann; Kutlay Şehim Kutlay; Helena Mäenpää; Volker Mall; Paul McArthur; Edith Morel; Antigone Papavassiliou; Ignacio Pascual-Pascual; Søren Anker Pedersen; Frank S. Plasschaert; van der Ploeg Irene van der Ploeg; Olivier Remy-Neris; Anne Renders; Guiseppe Di Rosa; Maja Steinlin; Kristina Tedroff; Joan Vidal Valls; Elke Viehweger; Guy Molenaers

doi:10.1016/j.ejpn.2009.09.005

The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy

Florian Heinen
, Kaat Desloovere
, A. Sebastian Schroeder
, Steffen Berweck
, Ingo Borggraefe
, Anya van Campenhout
, Guro L. Andersen
, Resa Aydin
, Jules G. Becher
, Günther Bernert
, Ignacio Martinez Caballero
, Lucinda Carr
, Emmanuelle Chaleat Valayer
, Maria Teresa Desiato
, Charlie Fairhurst
, Paul Filipetti
, Ralph Ingo Hassink
, Ulf Hustedt
, Marek Jozwiak
, Serdar Ibrahim Kocer

Elisabeth Kolanowski, Ingeborg Krägeloh-Mann, Kutlay Şehim Kutlay, Helena Mäenpää, Volker Mall, Paul McArthur, Edith Morel, Antigone Papavassiliou, Ignacio Pascual-Pascual, Søren Anker Pedersen, Frank S. Plasschaert, van der Ploeg Irene van der Ploeg, Olivier Remy-Neris, Anne Renders, Guiseppe Di Rosa, Maja Steinlin, Kristina Tedroff, Joan Vidal Valls, Elke Viehweger, Guy Molenaers

Ludwig-Maximilians-Universität München
Leuven University Center for Metabolic Bone Diseases
Epilepsy Centre for Children and Adolescents
Habilitation Center
Cerrahpasa Medical School
Amsterdam University Medical Centers
Gottfried von Preyer'sches Kinderspital der Stadt Wien
Hospital Infantil Universitario Niño Jesus
Great Ormond Street Hospital for Children NHS Foundation Trust
Centre médico-chirurgical et de réadaptation des Massues
S. Eugenio Hospital
Guy's and St. Thomas' National Health Service Foundation Trust
Motion Lab Analysis. Rehazenter
Zentrum fur Entwicklungsforderung und padiatrische Neurorehabilitation (Z.E.N.) der Stiftung Wilderm
Hospital of the City of Frankfurt
Poznan University of Medical Sciences
Centra Med Physique Réeducation
Centre de Rééducation Fonctionnelle Marc Sautelet-APF
University of Tübingen
Ankara University School of Medicine
Hospital for Children and Adolescents
Albert-Ludwigs-Universität Freiburg
Alder Hey Children’s Hospital
Pendeli Children's Hospital
Universidad Autónoma de Madrid
Copenhagen University Hospital Hvidovre
Ghent University Hospital
University Hospitals Coventry and Warwickshire NHS Trust
Service de Génétique
Clinique Universitaire St-Luc
Ospedale Pediatrico Bambino Gesù
Inselspital Universitatsspital
Karolinska Institutet
Centre Pilot Arcàngel Sant Gabriel
Hôpital La Timone

Research output: Contribution to journal › Review article › peer-review

266 Scopus citations

Abstract

An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years. In part II of the consensus the Gross Motor Function Measure (GMFM) and Gross Motor Function Classification System (GMFCS) based Motor Development Curves have been expanded to provide a graphical framework on how to treat the motor disorders in children with CP. This graph is named "CP^Graph Treatment Modalities - Gross Motor Function" and is intended to facilitate communication between parents, therapists and medical doctors concerning (1) achievable motor function, (2) realistic goal-setting and (3) treatment perspectives for children with CP. The updated European consensus 2009 summarises the current understanding regarding an integrated, multidisciplinary treatment approach using Botulinum toxin for the treatment of children with CP.

Original language	English
Pages (from-to)	45-66
Number of pages	22
Journal	European Journal of Paediatric Neurology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.ejpn.2009.09.005
State	Published - Jan 2010
Externally published	Yes

Keywords

Botulinum toxin
Cerebral palsy

Access to Document

10.1016/j.ejpn.2009.09.005

Cite this

Heinen, F., Desloovere, K., Schroeder, A. S., Berweck, S., Borggraefe, I., van Campenhout, A., Andersen, G. L., Aydin, R., Becher, J. G., Bernert, G., Caballero, I. M., Carr, L., Valayer, E. C., Desiato, M. T., Fairhurst, C., Filipetti, P., Hassink, R. I., Hustedt, U., Jozwiak, M., ... Molenaers, G. (2010). The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy. European Journal of Paediatric Neurology, 14(1), 45-66. https://doi.org/10.1016/j.ejpn.2009.09.005

@article{505c1dbe951345aebe1b3cc4e4d03987,

title = "The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy",

abstract = "An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years. In part II of the consensus the Gross Motor Function Measure (GMFM) and Gross Motor Function Classification System (GMFCS) based Motor Development Curves have been expanded to provide a graphical framework on how to treat the motor disorders in children with CP. This graph is named {"}CPGraph Treatment Modalities - Gross Motor Function{"} and is intended to facilitate communication between parents, therapists and medical doctors concerning (1) achievable motor function, (2) realistic goal-setting and (3) treatment perspectives for children with CP. The updated European consensus 2009 summarises the current understanding regarding an integrated, multidisciplinary treatment approach using Botulinum toxin for the treatment of children with CP.",

keywords = "Botulinum toxin, Cerebral palsy",

author = "Florian Heinen and Kaat Desloovere and Schroeder, \{A. Sebastian\} and Steffen Berweck and Ingo Borggraefe and \{van Campenhout\}, Anya and Andersen, \{Guro L.\} and Resa Aydin and Becher, \{Jules G.\} and G{\"u}nther Bernert and Caballero, \{Ignacio Martinez\} and Lucinda Carr and Valayer, \{Emmanuelle Chaleat\} and Desiato, \{Maria Teresa\} and Charlie Fairhurst and Paul Filipetti and Hassink, \{Ralph Ingo\} and Ulf Hustedt and Marek Jozwiak and Kocer, \{Serdar Ibrahim\} and Elisabeth Kolanowski and Ingeborg Kr{\"a}geloh-Mann and \{{\c S}ehim Kutlay\}, Kutlay and Helena M{\"a}enp{\"a}{\"a} and Volker Mall and Paul McArthur and Edith Morel and Antigone Papavassiliou and Ignacio Pascual-Pascual and Pedersen, \{S{\o}ren Anker\} and Plasschaert, \{Frank S.\} and \{Irene van der Ploeg\}, \{van der Ploeg\} and Olivier Remy-Neris and Anne Renders and \{Di Rosa\}, Guiseppe and Maja Steinlin and Kristina Tedroff and Valls, \{Joan Vidal\} and Elke Viehweger and Guy Molenaers",

note = "Funding Information: Dr. Heinen and Dr. Berweck have received speaker's honoraria, research support and travel grants from manufacturers of the different BoNT preparations available (Allergan, Germany, IPSEN, Germany, Merz Pharmaceuticals, Germany). Dr. Schroeder reports having received lecture fees and travel grants from Allergan, Germany. ",

year = "2010",

month = jan,

doi = "10.1016/j.ejpn.2009.09.005",

language = "English",

volume = "14",

pages = "45--66",

journal = "European Journal of Paediatric Neurology",

issn = "1090-3798",

publisher = "W.B. Saunders Ltd",

number = "1",

}

Heinen, F, Desloovere, K, Schroeder, AS, Berweck, S, Borggraefe, I, van Campenhout, A, Andersen, GL, Aydin, R, Becher, JG, Bernert, G, Caballero, IM, Carr, L, Valayer, EC, Desiato, MT, Fairhurst, C, Filipetti, P, Hassink, RI, Hustedt, U, Jozwiak, M, Kocer, SI, Kolanowski, E, Krägeloh-Mann, I, Şehim Kutlay, K, Mäenpää, H, Mall, V, McArthur, P, Morel, E, Papavassiliou, A, Pascual-Pascual, I, Pedersen, SA, Plasschaert, FS, Irene van der Ploeg, VDP, Remy-Neris, O, Renders, A, Di Rosa, G, Steinlin, M, Tedroff, K, Valls, JV, Viehweger, E & Molenaers, G 2010, 'The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy', European Journal of Paediatric Neurology, vol. 14, no. 1, pp. 45-66. https://doi.org/10.1016/j.ejpn.2009.09.005

TY - JOUR

T1 - The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy

AU - Heinen, Florian

AU - Desloovere, Kaat

AU - Schroeder, A. Sebastian

AU - Berweck, Steffen

AU - Borggraefe, Ingo

AU - van Campenhout, Anya

AU - Andersen, Guro L.

AU - Aydin, Resa

AU - Becher, Jules G.

AU - Bernert, Günther

AU - Caballero, Ignacio Martinez

AU - Carr, Lucinda

AU - Valayer, Emmanuelle Chaleat

AU - Desiato, Maria Teresa

AU - Fairhurst, Charlie

AU - Filipetti, Paul

AU - Hassink, Ralph Ingo

AU - Hustedt, Ulf

AU - Jozwiak, Marek

AU - Kocer, Serdar Ibrahim

AU - Kolanowski, Elisabeth

AU - Krägeloh-Mann, Ingeborg

AU - Şehim Kutlay, Kutlay

AU - Mäenpää, Helena

AU - Mall, Volker

AU - McArthur, Paul

AU - Morel, Edith

AU - Papavassiliou, Antigone

AU - Pascual-Pascual, Ignacio

AU - Pedersen, Søren Anker

AU - Plasschaert, Frank S.

AU - Irene van der Ploeg, van der Ploeg

AU - Remy-Neris, Olivier

AU - Renders, Anne

AU - Di Rosa, Guiseppe

AU - Steinlin, Maja

AU - Tedroff, Kristina

AU - Valls, Joan Vidal

AU - Viehweger, Elke

AU - Molenaers, Guy

N1 - Funding Information: Dr. Heinen and Dr. Berweck have received speaker's honoraria, research support and travel grants from manufacturers of the different BoNT preparations available (Allergan, Germany, IPSEN, Germany, Merz Pharmaceuticals, Germany). Dr. Schroeder reports having received lecture fees and travel grants from Allergan, Germany.

PY - 2010/1

Y1 - 2010/1

N2 - An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years. In part II of the consensus the Gross Motor Function Measure (GMFM) and Gross Motor Function Classification System (GMFCS) based Motor Development Curves have been expanded to provide a graphical framework on how to treat the motor disorders in children with CP. This graph is named "CPGraph Treatment Modalities - Gross Motor Function" and is intended to facilitate communication between parents, therapists and medical doctors concerning (1) achievable motor function, (2) realistic goal-setting and (3) treatment perspectives for children with CP. The updated European consensus 2009 summarises the current understanding regarding an integrated, multidisciplinary treatment approach using Botulinum toxin for the treatment of children with CP.

AB - An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years. In part II of the consensus the Gross Motor Function Measure (GMFM) and Gross Motor Function Classification System (GMFCS) based Motor Development Curves have been expanded to provide a graphical framework on how to treat the motor disorders in children with CP. This graph is named "CPGraph Treatment Modalities - Gross Motor Function" and is intended to facilitate communication between parents, therapists and medical doctors concerning (1) achievable motor function, (2) realistic goal-setting and (3) treatment perspectives for children with CP. The updated European consensus 2009 summarises the current understanding regarding an integrated, multidisciplinary treatment approach using Botulinum toxin for the treatment of children with CP.

KW - Botulinum toxin

KW - Cerebral palsy

UR - https://www.scopus.com/pages/publications/71949092112

U2 - 10.1016/j.ejpn.2009.09.005

DO - 10.1016/j.ejpn.2009.09.005

M3 - Review article

C2 - 19914110

AN - SCOPUS:71949092112

SN - 1090-3798

VL - 14

SP - 45

EP - 66

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

IS - 1

ER -

The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy

Abstract

Keywords

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