The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress

Keyphrases

• Unfolded Protein Response 100%
• Endoplasmic Reticulum Stress (ER stress) 100%
• ADAM17 100%
• Response Control 100%
• Severe Hypoxia 100%
• Stress Conditions 27%
• TNF Receptor 1 (TNFR1) 27%
• Tumor Necrosis Factor-α 18%
• Reactive Oxygen Species 9%
• Vascular Endothelial Growth Factor 9%
• MRNA Level 9%
• Mitogen-activated Protein Kinase 9%
• Inflammation 9%
• Endoplasmic Reticulum 9%
• Cancer Patients 9%
• Tumor Cell Lines 9%
• In Cancer 9%
• Hypoxia 9%
• Tumor Progression 9%
• Hypoxia-inducible factor-1α (HIF-1α) 9%
• Bevacizumab 9%
• Regulated Genes 9%
• Cancer Hallmarks 9%
• Thapsigargin 9%
• Activating Transcription Factor 4 (ATF4) 9%
• Xenograft 9%
• Metalloproteinases 9%
• Tumor Initiation 9%
• Activating Transcription Factor 6 (ATF6) 9%
• Disintegrin 9%
• Hypoxic Stress 9%
• Tumor Necrosis Factor-α Converting Enzyme 9%
• Ectodomain Shedding 9%
• EIF2 9%
• Severe Stress 9%
• Inhibitory Antibody 9%
• Moderate Hypoxia 9%
• Tumor Environment 9%

Biochemistry, Genetics and Molecular Biology

• ADAM17 100%
• Unfolded Protein Response 100%
• Endoplasmic Reticulum Stress 100%
• Tumor Necrosis Factor 27%
• Messenger RNA 9%
• Ectodomain 9%
• Enzyme 9%
• Hypoxia Inducible Factor 1 9%
• Tumor Initiation 9%
• Activating Transcription Factor 6 9%
• ATF4 9%
• Mitogen-Activated Protein Kinase 9%
• Vascular Endothelial Growth Factor 9%
• Metalloproteinase 9%
• Disintegrin 9%
• Tumor Progression 9%
• Metalloendopeptidase 9%
• Bevacizumab 9%