Abstract
Phagocytes, the prominent cells of innate immunity, are responsible for the removal of foreign invaders, apoptotic as well as cancer cells. In a flight experiment in the BIOLAB facility on the ISS we will investigate the combined effects of microgravity and cosmic radiation on the oxidative burst, the production of reactive oxygen species (ROS), of the macrophageal cell line NR8383. A chemiluminescence assay (luminol) is used to determine the amount of ROS during phagocytosis of zymosan in a kinetic approach. Ground control experiments for the TRIPLE LUX-A flight experiment on a fast rotating 2D clinostat showed that the selected cell line responds to simulated weightlessness by an increase of ROSproduction.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the Symposium Life in Space for Life on Earth |
| State | Published - 2008 |
| Event | Life in Space for Life on Earth - Angers, France Duration: 22 Jun 2008 → 27 Jul 2008 |
Publication series
| Name | European Space Agency, (Special Publication) ESA SP |
|---|---|
| Volume | 663 SP |
| ISSN (Print) | 0379-6566 |
Conference
| Conference | Life in Space for Life on Earth |
|---|---|
| Country/Territory | France |
| City | Angers |
| Period | 22/06/08 → 27/07/08 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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