The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease

Zoltan Keresztenyi; Peter Valkovič; Thomas Eggert; Ulrich Steude; Joachim Hermsdörfer; Jozsef Laczko; Kai Bötzel

doi:10.1016/j.parkreldis.2006.12.003

The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease

Zoltan Keresztenyi, Peter Valkovič, Thomas Eggert, Ulrich Steude, Joachim Hermsdörfer, Jozsef Laczko, Kai Bötzel

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

To investigate the time span within which bradykinesia re-occurs, we registered movement parameters immediately after the termination of deep brain stimulation of the subthalamic nucleus (STN) in nine Parkinson patients with chronically implanted bilateral STN electrodes. Two repetitive movements were investigated: finger-tapping and forearm pronation-supination. When stimulation was switched off, the amplitude and velocity of the investigated movements significantly declined, but the frequency did not. The time course of this decline was modeled by an exponential function that yielded time constants between 15 and 30 s. The effect of stimulation had completely disappeared within 1 min. These results suggest that it is necessary to wait at least for 1 min after the end of stimulation before performing further assessments.

Original language	English
Pages (from-to)	438-442
Number of pages	5
Journal	Parkinsonism and Related Disorders
Volume	13
Issue number	7
DOIs	https://doi.org/10.1016/j.parkreldis.2006.12.003
State	Published - Oct 2007
Externally published	Yes

Keywords

Bradykinesia
Parkinson's disease
Subthalamic stimulation

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10.1016/j.parkreldis.2006.12.003

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title = "The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease",

abstract = "To investigate the time span within which bradykinesia re-occurs, we registered movement parameters immediately after the termination of deep brain stimulation of the subthalamic nucleus (STN) in nine Parkinson patients with chronically implanted bilateral STN electrodes. Two repetitive movements were investigated: finger-tapping and forearm pronation-supination. When stimulation was switched off, the amplitude and velocity of the investigated movements significantly declined, but the frequency did not. The time course of this decline was modeled by an exponential function that yielded time constants between 15 and 30 s. The effect of stimulation had completely disappeared within 1 min. These results suggest that it is necessary to wait at least for 1 min after the end of stimulation before performing further assessments.",

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AU - Keresztenyi, Zoltan

AU - Valkovič, Peter

AU - Eggert, Thomas

AU - Steude, Ulrich

AU - Hermsdörfer, Joachim

AU - Laczko, Jozsef

AU - Bötzel, Kai

PY - 2007/10

Y1 - 2007/10

N2 - To investigate the time span within which bradykinesia re-occurs, we registered movement parameters immediately after the termination of deep brain stimulation of the subthalamic nucleus (STN) in nine Parkinson patients with chronically implanted bilateral STN electrodes. Two repetitive movements were investigated: finger-tapping and forearm pronation-supination. When stimulation was switched off, the amplitude and velocity of the investigated movements significantly declined, but the frequency did not. The time course of this decline was modeled by an exponential function that yielded time constants between 15 and 30 s. The effect of stimulation had completely disappeared within 1 min. These results suggest that it is necessary to wait at least for 1 min after the end of stimulation before performing further assessments.

AB - To investigate the time span within which bradykinesia re-occurs, we registered movement parameters immediately after the termination of deep brain stimulation of the subthalamic nucleus (STN) in nine Parkinson patients with chronically implanted bilateral STN electrodes. Two repetitive movements were investigated: finger-tapping and forearm pronation-supination. When stimulation was switched off, the amplitude and velocity of the investigated movements significantly declined, but the frequency did not. The time course of this decline was modeled by an exponential function that yielded time constants between 15 and 30 s. The effect of stimulation had completely disappeared within 1 min. These results suggest that it is necessary to wait at least for 1 min after the end of stimulation before performing further assessments.

KW - Bradykinesia

KW - Parkinson's disease

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The time course of the return of upper limb bradykinesia after cessation of subthalamic stimulation in Parkinson's disease

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Keywords

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