The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

Mathias Gehrmann; Jürgen Radons; Michael Molls; Gabriele Multhoff

doi:10.1007/s12192-007-0006-0

The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

Mathias Gehrmann, Jürgen Radons, Michael Molls, Gabriele Multhoff

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Abstract

Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stressinducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.

Original language	English
Pages (from-to)	1-10
Number of pages	10
Journal	Cell Stress and Chaperones
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s12192-007-0006-0
State	Published - Mar 2008

Keywords

Hsp70
Membrane expression
NK cell
Stress response modifiers
Tumor

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10.1007/s12192-007-0006-0

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abstract = "Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stressinducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.",

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The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

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Keywords

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