The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells

Mathias Gehrmann, Jürgen Radons, Michael Molls, Gabriele Multhoff

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Evidence that membrane-bound and extracellular heat shock proteins (HSPs) with molecular weights of 70 and 90 kDa are potent stimulators of the immune responses has accumulated over the last decade. In this review, we discuss the modulation of Hsp70 expression, a major stressinducible member of the HSP70 family, in the cytoplasm and on the plasma membrane of tumor cells by clinically applied interventions such as radio- and chemotherapy.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalCell Stress and Chaperones
Volume13
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Hsp70
  • Membrane expression
  • NK cell
  • Stress response modifiers
  • Tumor

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