The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters

Marong Qin; Pawan Mishra; Jasmine Hind; Ian A. Fallis; Matthew Tredwell

doi:10.1039/d5cc05507e

The synthesis of [¹⁸F]SynVesT-1 and [¹⁸F]SynVesT-2 from enantioenriched boronic esters

Marong Qin
, Pawan Mishra
, Jasmine Hind
, Ian A. Fallis
, Matthew Tredwell

Cardiff University
Cardiff University School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Enantioenriched [¹⁸F]SynVesT-1 and [¹⁸F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [¹⁸F]fluoride mediated by (Py)₄Cu(OTf)₂. The ¹⁸F-reaction is optimised on an automated synthesiser to produce multi-GBq quantities of both radiotracers to support (pre)clinical imaging.

Original language	English
Pages (from-to)	17689-17692
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	90
DOIs	https://doi.org/10.1039/d5cc05507e
State	Published - 21 Nov 2025
Externally published	Yes

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title = "The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters",

abstract = "Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantities of both radiotracers to support (pre)clinical imaging.",

author = "Marong Qin and Pawan Mishra and Jasmine Hind and Fallis, \{Ian A.\} and Matthew Tredwell",

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AU - Qin, Marong

AU - Mishra, Pawan

AU - Hind, Jasmine

AU - Fallis, Ian A.

AU - Tredwell, Matthew

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry, 2025

PY - 2025/11/21

Y1 - 2025/11/21

N2 - Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantities of both radiotracers to support (pre)clinical imaging.

AB - Enantioenriched [18F]SynVesT-1 and [18F]SynVesT-2 are prepared from the corresponding enantioenriched arylboronic esters and [18F]fluoride mediated by (Py)4Cu(OTf)2. The 18F-reaction is optimised on an automated synthesiser to produce multi-GBq quantities of both radiotracers to support (pre)clinical imaging.

UR - https://www.scopus.com/pages/publications/105021140218

U2 - 10.1039/d5cc05507e

DO - 10.1039/d5cc05507e

M3 - Article

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AN - SCOPUS:105021140218

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JO - Chemical Communications

JF - Chemical Communications

IS - 90

ER -

The synthesis of [¹⁸F]SynVesT-1 and [¹⁸F]SynVesT-2 from enantioenriched boronic esters

Abstract

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