The Structure of the Polycyclic Nonadecapeptide Ro 09‐0198

Horst Kessler; Stefan Steuernagel; Martin Will; Günther Jung; Roland Kellner; Dieter Gillessen; Tsutomu Kamiyama

doi:10.1002/hlca.19880710811

The Structure of the Polycyclic Nonadecapeptide Ro 09‐0198

Horst Kessler, Stefan Steuernagel, Martin Will, Günther Jung, Roland Kellner, Dieter Gillessen, Tsutomu Kamiyama

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The conventional determination of the amino‐acid sequence of the peptide antibiotic Ro 09‐0198 was prevented by four cyclizations via side chains. The joint application of NMR spectroscopy at highest field and automated Edman degradation yielded a complete determination of the connectivity pattern. The three‐dimensional structure derived from NOE data exhibits an interesting separation of amino acids with hydrophilic and hydrophobic side chains.

Original language	English
Pages (from-to)	1924-1929
Number of pages	6
Journal	Helvetica Chimica Acta
Volume	71
Issue number	8
DOIs	https://doi.org/10.1002/hlca.19880710811
State	Published - 14 Dec 1988
Externally published	Yes

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abstract = "The conventional determination of the amino‐acid sequence of the peptide antibiotic Ro 09‐0198 was prevented by four cyclizations via side chains. The joint application of NMR spectroscopy at highest field and automated Edman degradation yielded a complete determination of the connectivity pattern. The three‐dimensional structure derived from NOE data exhibits an interesting separation of amino acids with hydrophilic and hydrophobic side chains.",

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AU - Steuernagel, Stefan

AU - Will, Martin

AU - Jung, Günther

AU - Kellner, Roland

AU - Gillessen, Dieter

AU - Kamiyama, Tsutomu

PY - 1988/12/14

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AB - The conventional determination of the amino‐acid sequence of the peptide antibiotic Ro 09‐0198 was prevented by four cyclizations via side chains. The joint application of NMR spectroscopy at highest field and automated Edman degradation yielded a complete determination of the connectivity pattern. The three‐dimensional structure derived from NOE data exhibits an interesting separation of amino acids with hydrophilic and hydrophobic side chains.

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The Structure of the Polycyclic Nonadecapeptide Ro 09‐0198

Abstract

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