The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates

Ana Casañal; Ulrich Zander; Cristina Muñoz; Florine Dupeux; Irene Luque; Miguel Angel Botella; Wilfried Schwab; Victoriano Valpuesta; José A. Marquez

doi:10.1074/jbc.M113.501528

The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates

Ana Casañal
, Ulrich Zander
, Cristina Muñoz
, Florine Dupeux
, Irene Luque
, Miguel Angel Botella
, Wilfried Schwab
, Victoriano Valpuesta
, José A. Marquez

Associate Professorship of Biotechnology of Natural Products

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.

Original language	English
Pages (from-to)	35322-35332
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	49
DOIs	https://doi.org/10.1074/jbc.M113.501528
State	Published - 6 Dec 2013

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abstract = "Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.",

author = "Ana Casa{\~n}al and Ulrich Zander and Cristina Mu{\~n}oz and Florine Dupeux and Irene Luque and Botella, \{Miguel Angel\} and Wilfried Schwab and Victoriano Valpuesta and Marquez, \{Jos{\'e} A.\}",

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T1 - The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates

AU - Casañal, Ana

AU - Zander, Ulrich

AU - Muñoz, Cristina

AU - Dupeux, Florine

AU - Luque, Irene

AU - Botella, Miguel Angel

AU - Schwab, Wilfried

AU - Valpuesta, Victoriano

AU - Marquez, José A.

PY - 2013/12/6

Y1 - 2013/12/6

N2 - Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.

AB - Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.

UR - https://www.scopus.com/pages/publications/84890284062

U2 - 10.1074/jbc.M113.501528

DO - 10.1074/jbc.M113.501528

M3 - Article

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AN - SCOPUS:84890284062

SN - 0021-9258

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EP - 35332

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 49

ER -

The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates

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