TY - JOUR
T1 - The strawberry pathogenesis-related 10 (PR-10) Fra a proteins control flavonoid biosynthesis by binding to metabolic intermediates
AU - Casañal, Ana
AU - Zander, Ulrich
AU - Muñoz, Cristina
AU - Dupeux, Florine
AU - Luque, Irene
AU - Botella, Miguel Angel
AU - Schwab, Wilfried
AU - Valpuesta, Victoriano
AU - Marquez, José A.
PY - 2013/12/6
Y1 - 2013/12/6
N2 - Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.
AB - Background: Suppression of Fra a gene expression leads to down-regulation of color-producing flavonoid biosynthesis in strawberry. Results: Fra proteins can bind natural flavonoids, which induce conformational changes in conserved loop regions. Conclusion: Fra a proteins control flavonoid biosynthesis through binding to metabolic intermediates. Significance: PR-10 proteins may play a role in the control of secondary metabolism through binding of metabolites to their ligand-binding cavities.
UR - http://www.scopus.com/inward/record.url?scp=84890284062&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.501528
DO - 10.1074/jbc.M113.501528
M3 - Article
C2 - 24133217
AN - SCOPUS:84890284062
SN - 0021-9258
VL - 288
SP - 35322
EP - 35332
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 49
ER -